Seroatlas · Human Serome Atlas

ID3

DNA-binding protein inhibitor ID-3

Also known as: bHLHb25, HEIR-1, ID3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02535
Gene: ID3
Ensembl: ENSG00000117318
Chromosome: 1
Canonical length: 119 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>Q02535|ID3
     1  MKALSPVRGC YEAVCCLSER SLAIARGRGK GPAAEEPLSL LDDMNHCYSR LRELVPGVPR
    61  GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ TAELTPELVI SNDKRSFCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ID3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 461 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 461 nTPM
thyroid gland: 284 nTPM
heart muscle: 266 nTPM
adipose tissue: 230 nTPM
urinary bladder: 222 nTPM
kidney: 188 nTPM

Single-cell type

astrocytes: 123 nCPM
endometrial luminal cells: 49 nCPM
vascular endothelial cells: 41 nCPM
endometrial secretory cells: 41 nCPM
hepatic stellate cells: 39 nCPM
vascular smooth muscle cells: 35 nCPM

Immune cell

memory B-cell: 320 nTPM
naive B-cell: 308 nTPM
T-reg: 178 nTPM
naive CD4 T-cell: 114 nTPM
memory CD4 T-cell: 70 nTPM
naive CD8 T-cell: 46 nTPM

Brain region

hypothalamus: 104 nTPM
medulla oblongata: 78 nTPM
thalamus: 66 nTPM
midbrain: 64 nTPM
spinal cord: 55 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.72
gnomAD missense Z: -1.02
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ID3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ID3 as an antibody target. Whether an autoantibody or antibody against ID3 could matter depends on whether native ID3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ID3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ID3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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