JAB1/MPN/MOV34 metalloenzyme domain
IPR000555
Definition
This domain is known as the MPN domain PMID:9644972, PAD-1-like domain PMID:10369758, JABP1 domain PMID:20838651 or JAMM domain PMID:12183636. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/deubiquitinase in the ubiquitin-based signalling and protein turnover pathways in eukaryotes PMID:12183636. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role PMID:16859499. The archaeal (H. volcanii) JAMM domain containing protein, HvJAMM1, cleaves ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates PMID:22970855. The bacterial JAMM domain containing protein QbsD from Pseudomonas fluorescens cleaves the C-terminal amino acid residues of the sulfur carrier protein QbsE prior to the formation of the carboxy-terminal thiocarboxylate PMID:17209031.
12 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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