JAMM/MPN+ metalloenzymes, peptidase M67A

Definition

The peptidase M67A family, also known as the JAMM/MPN+ metalloenzymes, encompasses proteins with diverse functions related to ubiquitin signaling and protein homeostasis. Members of this family are involved in the cleavage of 'Lys-63'-linked polyubiquitin chains, regulating processes such as DNA damage response, cell cycle progression, and immune signaling. They are components of various multiprotein complexes, including the BRCA1-A complex, which targets DNA damage sites, and the BRISC complex, which is essential for mitotic spindle assembly. The family also includes subunits of the COP9 signalosome, which regulates ubiquitin conjugation pathways, and the 26S proteasome, which degrades ubiquitinated proteins. Additionally, they play roles in translation initiation as part of the eIF-3 complex, targeting specific mRNAs for protein synthesis. This family is characterized by the presence of a JAMM motif, which is crucial for their protease activity, and some members also contain SANT and SWIRM domains for DNA binding and chromatin association.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• BRCC3
• COPS5
• EIF3H
• MPND
• MYSM1
• PSMD14