Seroatlas · Human Serome Atlas

COPS2

COP9 signalosome complex subunit 2

Also known as: ALIEN, CSN2, CSN2_HUMAN, TRIP15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61201
Gene
COPS2
Ensembl
ENSG00000166200
Chromosome
15
Canonical length
443 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytokinetic bridge

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm and nucleus. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>P61201|COPS2
     1  MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL
    61  EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS
   121  TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ
   181  TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC
   241  GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
   301  PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI
   361  KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR
   421  YTALDKWTNQ LNSLNQAVVS KLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
118 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 118 nTPM
  • tongue: 105 nTPM
  • skeletal muscle: 85 nTPM
  • ovary: 76 nTPM
  • breast: 63 nTPM
  • parathyroid gland: 62 nTPM

Single-cell type

  • syncytiotrophoblasts: 181 nCPM
  • esophageal apical cells: 158 nCPM
  • late primary spermatocytes: 137 nCPM
  • endometrial glandular cells: 122 nCPM
  • endometrial luminal cells: 114 nCPM
  • suprabasal keratinocytes: 113 nCPM

Immune cell

  • T-reg: 28 nTPM
  • naive CD4 T-cell: 25 nTPM
  • MAIT T-cell: 25 nTPM
  • intermediate monocyte: 24 nTPM
  • non-classical monocyte: 23 nTPM
  • myeloid DC: 21 nTPM

Brain region

  • white matter: 81 nTPM
  • spinal cord: 70 nTPM
  • cerebellum: 69 nTPM
  • pons: 65 nTPM
  • medulla oblongata: 62 nTPM
  • hypothalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
4.13
DepMap mean gene effect
-1.29
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS2 as an antibody target. Whether an autoantibody or antibody against COPS2 could matter depends on whether native COPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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