Seroatlas · Human Serome Atlas

FANK1

Fibronectin type 3 and ankyrin repeat domains protein 1

Also known as: FANK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC84
Gene: FANK1
Ensembl: ENSG00000203780
Chromosome: 10
Canonical length: 345 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in regulation of DNA-templated transcription and regulation of apoptotic process. Located in chromatin; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q8TC84|FANK1
     1  MEPQKIMPPS KPHPPVVGKV THHSIELYWD LEKKAKRQGP QEQWFRFSIE EEDPKMHTYG
    61  IIYTGYATKH VVEGLEPRTL YRFRLKVTSP SGECEYSPLV SVSTTREPIS SEHLHRAVSV
   121  NDEDLLVRIL QGGRVKVDVP NKFGFTALMV AAQKGYTRLV KILVSNGTDV NLKNGSGKDS
   181  LMLACYAGHL DVVKYLRRHG ASWQARDLGG CTALHWAADG GHCSVIEWMI KDGCEVDVVD
   241  TGSGWTPLMR VSAVSGNQRV ASLLIDAGAN VNVKDRNGKT PLMVAVLNNH EELVQLLLDK
   301  GADASVKNEF GKGVLEMARV FDRQSVVSLL EERKKKQRPK KSCVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 65 nTPM
testis: 57 nTPM
fallopian tube: 33 nTPM
retina: 15 nTPM
epididymis: 11 nTPM
hypothalamus: 10 nTPM

Single-cell type

late spermatids: 815 nCPM
early spermatids: 691 nCPM
respiratory ciliated cells: 686 nCPM
ependymal cells: 605 nCPM
late primary spermatocytes: 505 nCPM
choroid plexus epithelial cells: 370 nCPM

Immune cell

T-reg: 61 nTPM
memory CD4 T-cell: 3.8 nTPM
total PBMC: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 70 nTPM
midbrain: 39 nTPM
medulla oblongata: 33 nTPM
spinal cord: 21 nTPM
pons: 17 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FANK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FANK1 as an antibody target. Whether an autoantibody or antibody against FANK1 could matter depends on whether native FANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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