Seroatlas · Human Serome Atlas

ID1

DNA-binding protein inhibitor ID-1

Also known as: bHLHb24, dJ857M17.1.2, ID1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41134
Gene
ID1
Ensembl
ENSG00000125968
Chromosome
20
Canonical length
155 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>P41134|ID1
     1  MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ
    61  QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG
   121  RGLPVRAPLS TLNGEISALT AEAACVPADD RILCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
379 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 379 nTPM
  • esophagus: 330 nTPM
  • heart muscle: 293 nTPM
  • thyroid gland: 255 nTPM
  • adipose tissue: 229 nTPM
  • lung: 199 nTPM

Single-cell type

  • esophageal apical cells: 3,645 nCPM
  • esophageal suprabasal cells: 2,030 nCPM
  • prostatic hillock cells: 1,927 nCPM
  • prostatic club cells: 1,685 nCPM
  • esophageal basal cells: 1,135 nCPM
  • endometrial luminal cells: 1,049 nCPM

Immune cell

  • neutrophil: 1.1 nTPM
  • eosinophil: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • thalamus: 130 nTPM
  • medulla oblongata: 103 nTPM
  • pons: 87 nTPM
  • choroid plexus: 81 nTPM
  • hypothalamus: 74 nTPM
  • midbrain: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
-2.01
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ID1 as an antibody target. Whether an autoantibody or antibody against ID1 could matter depends on whether native ID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ID1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ID1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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