BCL3

Protein identityUniProt · HPA

UniProt accession

P20749

Gene

BCL3

Ensembl

ENSG00000069399

Chromosome

19

Canonical length

454 aa

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Vesicles,Midbody,Basal body,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>P20749|BCL3
     1  MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL
    61  RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP
   121  LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV
   181  ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY
   241  DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA
   301  NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG
   361  KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN
   421  FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

169 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCL3.

Disease | ImmuneIEDB

Conditions an epitope on BCL3 was assayed in.

• nodular malignant melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

0.99

gnomAD missense Z

2.27

DepMap mean gene effect

0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antimicrobial humoral response
• canonical NF-kappaB signal transduction
• defense response to bacterium
• defense response to protozoan
• DNA damage response
• DNA damage response, signal transduction by p53 class mediator
• extracellular matrix organization
• follicular dendritic cell differentiation
• germinal center formation
• humoral immune response mediated by circulating immunoglobulin
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• marginal zone B cell differentiation
• negative regulation of apoptotic process
• negative regulation of DNA-templated transcription
• negative regulation of interleukin-8 production
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of receptor signaling pathway via JAK-STAT
• negative regulation of T cell apoptotic process
• negative regulation of tumor necrosis factor production
• positive regulation of DNA-templated transcription
• positive regulation of interleukin-10 production
• positive regulation of transcription by RNA polymerase II
• positive regulation of translation
• positive regulation of type II interferon production
• protein import into nucleus
• regulation of apoptotic process
• regulation of DNA binding
• regulation of non-canonical NF-kappaB signal transduction
• response to UV-C
• response to virus
• spleen development
• T cell apoptotic process
• T-helper 1 type immune response
• T-helper 2 cell differentiation

Molecular functions

• DNA-binding transcription factor binding
• histone deacetylase binding
• protein-macromolecule adaptor activity
• transcription coactivator activity
• transcription corepressor activity

Cellular components

• Bcl3/NF-kappaB2 complex
• ciliary basal body
• cytoplasm
• cytosol
• midbody
• nucleoplasm
• nucleus
• perinuclear region of cytoplasm
• protein-containing complex
• Bcl3-Bcl10 complex

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• NF-kappa-B Inhibitor
• Ankyrin repeat
• Ankyrin repeats (3 copies)

KeywordsUniProt

• Activator
• ANK repeat
• Chromosomal rearrangement
• Cytoplasm
• Nucleus
• Phosphoprotein
• Proto-oncogene
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of BCL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COPS5
• CYLD
• N4BP2
• PIR
• CTBP2