Seroatlas · Human Serome Atlas

COPS3

COP9 signalosome complex subunit 3

Also known as: CSN3, CSN3_HUMAN, SGN3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNS2
Gene
COPS3
Ensembl
ENSG00000141030
Chromosome
17
Canonical length
423 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9UNS2|COPS3
     1  MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA
    61  VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
   121  IGILKQAIDK MQMNTNQLTS IHADLCQLCL LAKCFKPALP YLDVDMMDIC KENGAYDAKH
   181  FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ
   241  LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS
   301  SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVSF
   361  HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGNKPS
   421  SYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 127 nTPM
  • bone marrow: 104 nTPM
  • tongue: 94 nTPM
  • testis: 71 nTPM
  • thymus: 48 nTPM
  • heart muscle: 47 nTPM

Single-cell type

  • late primary spermatocytes: 360 nCPM
  • oocytes: 221 nCPM
  • early primary spermatocytes: 180 nCPM
  • erythrocyte progenitors: 178 nCPM
  • esophageal basal cells: 143 nCPM
  • syncytiotrophoblasts: 137 nCPM

Immune cell

  • myeloid DC: 61 nTPM
  • total PBMC: 57 nTPM
  • neutrophil: 56 nTPM
  • non-classical monocyte: 53 nTPM
  • intermediate monocyte: 51 nTPM
  • T-reg: 48 nTPM

Brain region

  • cerebral cortex: 36 nTPM
  • hypothalamus: 32 nTPM
  • medulla oblongata: 29 nTPM
  • pons: 29 nTPM
  • white matter: 29 nTPM
  • cerebellum: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.37
DepMap mean gene effect
-0.73
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS3 as an antibody target. Whether an autoantibody or antibody against COPS3 could matter depends on whether native COPS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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