PGR

Protein identityUniProt · HPA

UniProt accession

P06401

Gene

PGR

Ensembl

ENSG00000082175

Chromosome

11

Canonical length

933 aa

Protein class

Cancer-related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors, Transporters

OverviewNCBI Gene

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

933 residues, UniProt reviewed canonical sequence.

>P06401|PGR
     1  MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF
    61  PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL LDSVLDTLLA
   121  PSGPGQSQPS PPACEVTSSW CLFGPELPED PPAAPATQRV LSPLMSRSGC KVGDSSGTAA
   181  AHKVLPRGLS PARQLLLPAS ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK
   241  PRALGGAAAG GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV
   301  MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS TPVAVGDFPD
   361  CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS PRSYLVAGAN PAAFPDFPLG
   421  PPPPLPPRAT PSRPGEAAVT AAPASASVSS ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC
   481  KAPGASGCLL PRDGLPSTSA SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP
   541  YLNYLRPDSE ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN
   601  YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA LDAVALPQPV
   661  GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY AGHDNTKPDT SSSLLTSLNQ
   721  LGERQLLSVV KWSKSLPGFR NLHIDDQITL IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP
   781  DLILNEQRMK ESSFYSLCLT MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ
   841  FEEMRSSYIR ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA
   901  LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

97 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for PGR from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.05

gnomAD missense Z

1.28

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• glandular epithelial cell maturation
• lung alveolus development
• maintenance of protein location in nucleus
• negative regulation of gene expression
• nuclear receptor-mediated steroid hormone signaling pathway
• ovulation from ovarian follicle
• paracrine signaling
• positive regulation of gene expression
• positive regulation of transcription by RNA polymerase II
• progesterone receptor signaling pathway
• regulation of DNA-templated transcription
• regulation of epithelial cell proliferation
• regulation of transcription by RNA polymerase II
• signal transduction
• tertiary branching involved in mammary gland duct morphogenesis

Molecular functions

• ATPase binding
• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• enzyme binding
• estrogen response element binding
• identical protein binding
• nuclear receptor activity
• nuclear steroid receptor activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• signaling receptor binding
• steroid binding
• transcription coactivator binding
• zinc ion binding

Cellular components

• chromatin
• cytosol
• mitochondrial outer membrane
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Nuclear hormone receptor, ligand-binding domain
• Zinc finger, nuclear hormone receptor-type
• Nuclear hormone receptor
• Zinc finger, NHR/GATA-type
• Nuclear hormone receptor-like domain superfamily
• Nuclear hormone receptor family NR3 subfamily
• Ligand-binding domain of nuclear hormone receptor
• Double treble clef zinc finger, C4 type
• Progesterone receptor
• Progesterone receptor

KeywordsUniProt

• Alternative promoter usage
• Cytoplasm
• DNA-binding
• Isopeptide bond
• Lipid-binding
• Lipoprotein
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion outer membrane
• Nucleus
• Palmitate
• Phosphoprotein
• Receptor
• Steroid-binding
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of PGR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUEDC2
• GTF2B
• KLF9
• NCOA1
• NCOA2
• NCOR2
• PIAS3
• PRMT2
• SMARD1
• SP1
• UNC45A
• COPS5
• SMARCD1
• DNAJC7
• POU2F2
• ZMIZ1
• POU2F1
• PNRC1
• PNRC2
• SMARCA4
• ESR1