Seroatlas · Human Serome Atlas

F2RL1

Proteinase-activated receptor 2

Also known as: GPR11, PAR2, PAR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55085
Gene
F2RL1
Ensembl
ENSG00000164251
Chromosome
5
Canonical length
397 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>P55085|F2RL1
     1  MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS
    61  VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA
   121  DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP
   181  MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF
   241  NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF
   301  TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL
   361  CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F2RL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • colon: 56 nTPM
  • rectum: 50 nTPM
  • duodenum: 43 nTPM
  • stomach: 42 nTPM
  • small intestine: 39 nTPM
  • skin: 37 nTPM

Single-cell type

  • foveolar cells: 142 nCPM
  • urothelial cells: 135 nCPM
  • suprabasal keratinocytes: 122 nCPM
  • colonocytes: 112 nCPM
  • ocular epithelial cells: 104 nCPM
  • enterocytes: 97 nCPM

Immune cell

  • neutrophil: 42 nTPM
  • basophil: 12 nTPM
  • classical monocyte: 10 nTPM
  • myeloid DC: 4.7 nTPM
  • total PBMC: 4 nTPM
  • memory CD4 T-cell: 3.8 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • midbrain: 4.6 nTPM
  • medulla oblongata: 3.7 nTPM
  • spinal cord: 2.3 nTPM
  • basal ganglia: 2.1 nTPM
  • thalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of F2RL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F2RL1 as an antibody target. Whether an autoantibody or antibody against F2RL1 could matter depends on whether native F2RL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F2RL1 is annotated at the cell surface, where native F2RL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label F2RL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/F2RL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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