Seroatlas · Human Serome Atlas

MINDY3

Ubiquitin carboxyl-terminal hydrolase MINDY-3

Also known as: C10orf97, CARP, DERP5, FAM188A, FLJ13397, MINY3_HUMAN, my042

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8M7
Gene
MINDY3
Ensembl
ENSG00000148481
Chromosome
10
Canonical length
445 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q9H8M7|MINDY3
     1  MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF
    61  LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD HSGSYCLVSW LRGKTTEETA
   121  SISGSPAESS CQVEHSSALA VEELGFERFH ALIQKRSFRS LPELKDAVLD QYSMWGNKFG
   181  VLLFLYSVLL TKGIENIKNE IEDASEPLID PVYGHGSQSL INLLLTGHAV SNVWDGDREC
   241  SGMKLLGIHE QAAVGFLTLM EALRYCKVGS YLKSPKFPIW IVGSETHLTV FFAKDMALVA
   301  PEAPSEQARR VFQTYDPEDN GFIPDSLLED VMKALDLVSD PEYINLMKNK LDPEGLGIIL
   361  LGPFLQEFFP DQGSSGPESF TVYHYNGLKQ SNYNEKVMYV EGTAVVMGFE DPMLQTDDTP
   421  IKRCLQTKWP YIELLWTTDR SPSLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINDY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 22 nTPM
  • adrenal gland: 21 nTPM
  • testis: 20 nTPM
  • placenta: 20 nTPM
  • epididymis: 19 nTPM
  • parathyroid gland: 19 nTPM

Single-cell type

  • neutrophil progenitors: 162 nCPM
  • hofbauer cells: 150 nCPM
  • pituitary stem cells: 100 nCPM
  • neutrophils: 97 nCPM
  • fibro-adipogenic progenitors: 95 nCPM
  • brain excitatory neurons: 95 nCPM

Immune cell

  • non-classical monocyte: 4 nTPM
  • intermediate monocyte: 3.5 nTPM
  • T-reg: 3.1 nTPM
  • basophil: 2.7 nTPM
  • memory CD8 T-cell: 2.4 nTPM
  • gdT-cell: 2.2 nTPM

Brain region

  • cerebellum: 66 nTPM
  • cerebral cortex: 60 nTPM
  • white matter: 55 nTPM
  • thalamus: 54 nTPM
  • basal ganglia: 54 nTPM
  • hippocampal formation: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.01
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MINDY3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINDY3 as an antibody target. Whether an autoantibody or antibody against MINDY3 could matter depends on whether native MINDY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINDY3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MINDY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MINDY3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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