Seroatlas · Human Serome Atlas

GPS1

COP9 signalosome complex subunit 1

Also known as: COPS1, CSN1, CSN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13098
Gene
GPS1
Ensembl
ENSG00000169727
Chromosome
17
Canonical length
491 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q13098|GPS1
     1  MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS YSGLMRIERL
    61  QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRSSLRELQ NAPDAIPESG
   121  VEPPALDTAW VEATRKKALL KLEKLDTDLK NYKGNSIKES IRRGHDDLGD HYLDCGDLSN
   181  ALKCYSRARD YCTSAKHVIN MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS
   241  QTQAILTKLK CAAGLAELAA RKYKQAAKCL LLASFDHCDF PELLSPSNVA IYGGLCALAT
   301  FDRQELQRNV ISSSSFKLFL ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP
   361  HVRTLYTQIR NRALIQYFSP YVSADMHRMA AAFNTTVAAL EDELTQLILE GLISARVDSH
   421  SKILYARDVD QRSTTFEKSL LMGKEFQRRA KAMMLRAAVL RNQIHVKSPP REGSQGELTP
   481  ANSQSRMSTN M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 143 nTPM
  • liver: 103 nTPM
  • heart muscle: 88 nTPM
  • kidney: 81 nTPM
  • cerebellum: 79 nTPM
  • hippocampal formation: 78 nTPM

Single-cell type

  • late spermatids: 137 nCPM
  • epididymal principal cells: 86 nCPM
  • cytotrophoblasts: 82 nCPM
  • esophageal suprabasal cells: 77 nCPM
  • extravillous trophoblasts: 76 nCPM
  • esophageal basal cells: 70 nCPM

Immune cell

  • T-reg: 116 nTPM
  • total PBMC: 99 nTPM
  • myeloid DC: 94 nTPM
  • classical monocyte: 86 nTPM
  • NK-cell: 83 nTPM
  • MAIT T-cell: 82 nTPM

Brain region

  • medulla oblongata: 82 nTPM
  • pons: 82 nTPM
  • midbrain: 79 nTPM
  • cerebellum: 77 nTPM
  • hippocampal formation: 77 nTPM
  • white matter: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.86
DepMap mean gene effect
-1
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPS1 as an antibody target. Whether an autoantibody or antibody against GPS1 could matter depends on whether native GPS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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