KLHDC2/KLHL20/DRC7 Kelch-repeats domain
PF24681
Definition
This entry represents a Kelch-repeats-like domain found in a diverse group of proteins, including KLHDC2, Kelch-like protein 20 and FBX42 from human, which are the substrate-recognition component of E3 ubiquitin-protein ligase complexes. KLHDC2 is the substrate-recognition component of Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognises a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation [[cite:PMID:29775578],[cite:PMID:30526872],[cite:PMID:38177675]]. KLHL20 and its orthologue from Drosophila diablo, are the substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, involved in interferon response and anterograde Golgi to endosome transport PMID:31279627. This domain can be found in DRC7 from C. reinhardtii and related sequences PMID:37258679.
37 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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