Seroatlas · Human Serome Atlas

CDK16

Cyclin-dependent kinase 16

Also known as: CDK16_HUMAN, FLJ16665, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00536
Gene
CDK16
Ensembl
ENSG00000102225
Chromosome
X
Canonical length
496 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Microtubules,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q00536|CDK16
     1  MDRMKKIKRQ LSMTLRGGRG IDKTNGAPEQ IGLDESGGGG GSDPGEAPTR AAPGELRSAR
    61  GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL
   121  PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY
   181  KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF
   241  EYLDKDLKQY LDDCGNIINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL
   301  KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP
   361  LFPGSTVEEQ LHFIFRILGT PTEETWPGIL SNEEFKTYNY PKYRAEALLS HAPRLDSDGA
   421  DLLTKLLQFE GRNRISAEDA MKHPFFLSLG ERIHKLPDTT SIFALKEIQL QKEASLRSSS
   481  MPDSGRPAFR VVDTEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
204 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 204 nTPM
  • tongue: 169 nTPM
  • cerebellum: 131 nTPM
  • heart muscle: 107 nTPM
  • cerebral cortex: 101 nTPM
  • amygdala: 85 nTPM

Single-cell type

  • late spermatids: 157 nCPM
  • esophageal apical cells: 94 nCPM
  • esophageal suprabasal cells: 75 nCPM
  • tuft cells: 69 nCPM
  • esophageal basal cells: 65 nCPM
  • ocular epithelial cells: 62 nCPM

Immune cell

  • plasmacytoid DC: 11 nTPM
  • naive B-cell: 9.9 nTPM
  • myeloid DC: 9.8 nTPM
  • intermediate monocyte: 9.3 nTPM
  • non-classical monocyte: 8.4 nTPM
  • classical monocyte: 7.8 nTPM

Brain region

  • thalamus: 152 nTPM
  • cerebral cortex: 144 nTPM
  • hippocampal formation: 132 nTPM
  • cerebellum: 130 nTPM
  • white matter: 120 nTPM
  • amygdala: 120 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK16.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
2.91
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK16 as an antibody target. Whether an autoantibody or antibody against CDK16 could matter depends on whether native CDK16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK16 is annotated at the cell surface, where native CDK16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDK16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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