Seroatlas · Human Serome Atlas

CDC25C

M-phase inducer phosphatase 3

Also known as: CDC25, MPIP3_HUMAN, PPP1R60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30307
Gene: CDC25C
Ensembl: ENSG00000158402
Chromosome: 5
Canonical length: 473 aa
Protein class: Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>P30307|CDC25C
     1  MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
    61  SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
   121  CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
   181  NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
   241  VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
   301  DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
   361  PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
   421  PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC25C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
thymus: 8.3 nTPM
bone marrow: 5.4 nTPM
tonsil: 4.3 nTPM
rectum: 3.8 nTPM
colon: 3.2 nTPM

Single-cell type

late primary spermatocytes: 92 nCPM
early spermatids: 91 nCPM
early primary spermatocytes: 72 nCPM
late spermatids: 63 nCPM
monocyte progenitors: 59 nCPM
oocytes: 51 nCPM

Immune cell

T-reg: 0.6 nTPM
NK-cell: 0.5 nTPM
memory B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 0.7 nTPM
midbrain: 0.6 nTPM
cerebral cortex: 0.5 nTPM
thalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM
choroid plexus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC25C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC25C as an antibody target. Whether an autoantibody or antibody against CDC25C could matter depends on whether native CDC25C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC25C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC25C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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