Seroatlas · Human Serome Atlas

CDK14

Cyclin-dependent kinase 14

Also known as: CDK14_HUMAN, PFTAIRE1, PFTK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94921
Gene
CDK14
Ensembl
ENSG00000058091
Chromosome
7
Canonical length
469 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>O94921|CDK14
     1  MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKDDTTFD EICVTKMSTR NCQGMDSVIK
    61  PLDTIPEDKK VRVQRTQSTF DPFEKPANQV KRVHSENNAC INFKTSSTGK ESPKVRRHSS
   121  PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL VALKVIRLQE EEGTPFTAIR
   181  EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY MDKHPGGLHP DNVKLFLFQL
   241  LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA KSVPSHTYSN EVVTLWYRPP
   301  DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD QLERIFLVLG TPNEDTWPGV
   361  HSLPHFKPER FTLYSSKNLR QAWNKLSYVN HAEDLASKLL QCSPKNRLSA QAALSHEYFS
   421  DLPPRLWELT DMSSIFTVPN VRLQPEAGES MRAFGKNNSY GKSLSNSKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 32 nTPM
  • cerebellum: 20 nTPM
  • hippocampal formation: 19 nTPM
  • kidney: 19 nTPM
  • amygdala: 18 nTPM
  • retina: 16 nTPM

Single-cell type

  • retinal horizontal cells: 1,302 nCPM
  • neutrophils: 1,015 nCPM
  • distal convoluted tubule cells: 797 nCPM
  • transitional alveolar cells: 785 nCPM
  • plasma cells: 738 nCPM
  • neutrophil progenitors: 726 nCPM

Immune cell

  • basophil: 9.1 nTPM
  • memory B-cell: 8.5 nTPM
  • naive B-cell: 4.8 nTPM
  • neutrophil: 4.8 nTPM
  • myeloid DC: 0.8 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • cerebral cortex: 98 nTPM
  • white matter: 75 nTPM
  • thalamus: 74 nTPM
  • midbrain: 73 nTPM
  • hippocampal formation: 66 nTPM
  • cerebellum: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
1.28
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK14 as an antibody target. Whether an autoantibody or antibody against CDK14 could matter depends on whether native CDK14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK14 is annotated at the cell surface, where native CDK14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDK14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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