Seroatlas · Human Serome Atlas

INAVA

Innate immunity activator protein

Also known as: C1orf106, FLJ10901, INAVA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3KP66
Gene
INAVA
Ensembl
ENSG00000163362
Chromosome
1
Canonical length
663 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nuclear body. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q3KP66|INAVA
     1  MLQMPKLNEI PPGRAGRREA RGEGRWPGQT GPEAARLEWR AQGQAGGARA PWDSWGSSRL
    61  PTQPGPGWSR CPPSLLCALS FQKSTMESKD EVSDTDSGII LQSGPDSPVS PMKELTHAVH
   121  KQQRALEARL EACLEELRRL CLREAELTGT LPAEYPLKPG EKAPKVRRRI GAAYKLDDWA
   181  LHREDPLSSL ERQLALQLQI TEAARRLCLE ENLSRQARRQ RKHSMLQEEK KLQELQRCLV
   241  ERRRNSEPPP AAALPLGREL SASDDSSLSD GLLLEEEESQ VPKPPPESPA PPSRPLPPQT
   301  LEGLQPTGPE AGSPERAPVQ NSPWKETSLD HPYEKPRKSS EPWSESSSPA TTPQDGPSAS
   361  SLWLLEPASY HVVPIRGVPG QWQGRTSAPA TPEIQGRRGQ SQSLRVDSFR AGPEGRGRSA
   421  FPRRRPTHYT VTVPDSCFPA TKPPLPHAAC HSCSEDSGSD VSSISHPTSP GSSSPDISFL
   481  QPLSPPKTHR HRGAWVPAGS RELVAHHPKL LLPPGYFPAG RYVVVAESPL PPGEWELRRA
   541  APGPAYEEEG TPLRYQRLVP SRSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
   601  TRPHSLDRQG AFRVRSLPLG REGFGRALGP RAQVPTVCVL RRSPDGAPVQ VFVPEKGEII
   661  SQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INAVA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 52 nTPM
  • duodenum: 45 nTPM
  • skin: 44 nTPM
  • esophagus: 42 nTPM
  • colon: 32 nTPM
  • rectum: 28 nTPM

Single-cell type

  • enterocytes: 212 nCPM
  • colonocytes: 113 nCPM
  • prostatic hillock cells: 97 nCPM
  • goblet cells: 93 nCPM
  • foveolar cells: 78 nCPM
  • paneth cells: 74 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 3.5 nTPM
  • thalamus: 2.8 nTPM
  • amygdala: 2.7 nTPM
  • basal ganglia: 2.7 nTPM
  • hypothalamus: 2.7 nTPM
  • cerebral cortex: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INAVA.

Disease | AllUniProt

Conditions INAVA is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INAVA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INAVA as an antibody target. Whether an autoantibody or antibody against INAVA could matter depends on whether native INAVA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INAVA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INAVA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INAVA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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