Seroatlas · Human Serome Atlas

SSH1

Protein phosphatase Slingshot homolog 1

Also known as: KIAA1298, SSH1_HUMAN, SSH1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WYL5
Gene: SSH1
Ensembl: ENSG00000084112
Chromosome: 12
Canonical length: 1049 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1049 residues, UniProt reviewed canonical sequence.

>Q8WYL5|SSH1
     1  MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL FLQQGSSPQG
    61  QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA WADRVRYMVV VYSSGRQDTE
   121  ENILLGVDFS SKESKSCTIG MVLRLWSDTK IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS
   181  ALQVLHKACE VARRHNYFPG GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL
   241  FVDKPTEGER TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML
   301  LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP GLFAYHNIRV
   361  YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS ASTVIAYAMK EFGWPLEKAY
   421  NYVKQKRSIT RPNAGFMRQL SEYEGILDAS KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL
   481  PETPDGTPES QLPFLDDAAQ PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL
   541  LEEAAPPAEV HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR
   601  WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA DCMYPTASGA
   661  PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV PEKPASGPTE PPPFLPPAGS
   721  RRADTSGPGA GAALEPPASL LEPSRETPKV LPKSLLLKNS HCDKNPPSTE VVIKEESSPK
   781  KDMKPAKDLR LLFSNESEKP TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA
   841  PPSRDGPASR LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP
   901  FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL VKQRTQEIET
   961  RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST VADSQDTTLS ESSFLHEPQG
  1021  TPRDPAATSK PSGKPAPENL KSPSWMSKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

lung: 11 nTPM
skeletal muscle: 11 nTPM
cerebellum: 9.6 nTPM
bone marrow: 7.4 nTPM
heart muscle: 7.3 nTPM
spleen: 7.1 nTPM

Single-cell type

neutrophils: 353 nCPM
lymphatic endothelial cells: 292 nCPM
vascular endothelial cells: 277 nCPM
microglia: 235 nCPM
pituicytes/fscs: 165 nCPM
myonuclei: 126 nCPM

Immune cell

neutrophil: 2.1 nTPM
eosinophil: 1.9 nTPM
basophil: 1.8 nTPM
intermediate monocyte: 1.5 nTPM
non-classical monocyte: 1.2 nTPM
gdT-cell: 1 nTPM

Brain region

cerebellum: 27 nTPM
choroid plexus: 23 nTPM
medulla oblongata: 21 nTPM
midbrain: 21 nTPM
hippocampal formation: 20 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dual specificity phosphatase, catalytic domain
Tyrosine-specific protein phosphatases domain
DEK, C-terminal
Protein-tyrosine phosphatase, active site
Dual specificity protein phosphatase domain
Protein-tyrosine phosphatase-like
Protein phosphatase Slingshot-like
Slingshot, N-terminal
Dual specificity phosphatase, catalytic domain
DEK C terminal domain
Protein phosphatase Slingshot homolog 1-like, PH domain-like
Protein phosphatase Slingshot homologue 1, dual specificity phosphatase domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSH1 as an antibody target. Whether an autoantibody or antibody against SSH1 could matter depends on whether native SSH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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