Seroatlas · Human Serome Atlas

TBC1D22A

TBC1 domain family member 22A

Also known as: C22orf4, TB22A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUA7
Gene: TBC1D22A
Ensembl: ENSG00000054611
Chromosome: 22
Canonical length: 517 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables 14-3-3 protein binding activity and protein homodimerization activity. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q8WUA7|TBC1D22A
     1  MASDGARKQF WKRSNSKLPG SIQHVYGAQH PPFDPLLHGT LLRSTAKMPT TPVKAKRVST
    61  FQEFESNTSD AWDAGEDDDE LLAMAAESLN SEVVMETANR VLRNHSQRQG RPTLQEGPGL
   121  QQKPRPEAEP PSPPSGDLRL VKSVSESHTS CPAESASDAA PLQRSQSLPH SATVTLGGTS
   181  DPSTLSSSAL SEREASRLDK FKQLLAGPNT DLEELRRLSW SGIPKPVRPM TWKLLSGYLP
   241  ANVDRRPATL QRKQKEYFAF IEHYYDSRND EVHQDTYRQI HIDIPRMSPE ALILQPKVTE
   301  IFERILFIWA IRHPASGYVQ GINDLVTPFF VVFICEYIEA EEVDTVDVSG VPAEVLCNIE
   361  ADTYWCMSKL LDGIQDNYTF AQPGIQMKVK MLEELVSRID EQVHRHLDQH EVRYLQFAFR
   421  WMNNLLMREV PLRCTIRLWD TYQSEPDGFS HFHLYVCAAF LVRWRKEILE EKDFQELLLF
   481  LQNLPTAHWD DEDISLLLAE AYRLKFAFAD APNHYKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D22A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spleen: 18 nTPM
lymph node: 18 nTPM
esophagus: 17 nTPM
tonsil: 17 nTPM
skeletal muscle: 17 nTPM
skin: 17 nTPM

Single-cell type

microglia: 865 nCPM
b-cells: 571 nCPM
cdc: 521 nCPM
neutrophils: 484 nCPM
macrophages: 401 nCPM
monocytes: 325 nCPM

Immune cell

non-classical monocyte: 19 nTPM
intermediate monocyte: 16 nTPM
neutrophil: 16 nTPM
naive B-cell: 13 nTPM
myeloid DC: 13 nTPM
memory B-cell: 12 nTPM

Brain region

midbrain: 23 nTPM
medulla oblongata: 23 nTPM
white matter: 23 nTPM
cerebral cortex: 22 nTPM
thalamus: 22 nTPM
pons: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBC1D22A.

Disease | ImmuneIEDB

Conditions an epitope on TBC1D22A was assayed in.

chronic lymphocytic leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.42
gnomAD missense Z: 1.2
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D22A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D22A as an antibody target. Whether an autoantibody or antibody against TBC1D22A could matter depends on whether native TBC1D22A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D22A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D22A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...