Seroatlas · Human Serome Atlas

CAMSAP3

Calmodulin-regulated spectrin-associated protein 3

Also known as: CAMP3_HUMAN, KIAA1543, Nezha, PPP1R80

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P1Y5
Gene
CAMSAP3
Ensembl
ENSG00000076826
Chromosome
19
Canonical length
1249 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables actin filament binding activity and microtubule minus-end binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of organelle organization; and zonula adherens maintenance. Located in cytoplasm; microtubule cytoskeleton; and zonula adherens. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1249 residues, UniProt reviewed canonical sequence.

>Q9P1Y5|CAMSAP3
     1  MVEAAPPGPG PLRRTFLVPE IKSLDQYDFS RAKAAASLAW VLRAAFGGAE HVPPELWEPF
    61  YTDQYAQEHV KPPVTRLLLS AELYCRAWRQ ALPQLETPPN PSALLALLAR RGTVPALPER
   121  PVREADLRHQ PILMGAHLAV IDALMAAFAF EWTKTLPGPL ALTSLEHKLL FWVDTTVRRL
   181  QEKTEQEAAQ RASPAAPADG AAPAQPSIRY RKDRVVARRA PCFPTVTSLQ DLASGAALAA
   241  TIHCYCPQLL RLEEVCLKDP MSVADSLYNL QLVQDFCASR LPRGCPLSLE DLLYVPPPLK
   301  VNLVVMLAEL FMCFEVLKPD FVQVKDLPDG HAASPRGTEA SPPQNNSGSS SPVFTFRHPL
   361  LSSGGPQSPL RGSTGSLKSS PSMSHMEALG KAWNRQLSRP LSQAVSFSTP FGLDSDVDVV
   421  MGDPVLLRSV SSDSLGPPRP APARTPTQPP PEPGDLPTIE EALQIIHSAE PRLLPDGAAD
   481  GSFYLHSPEG PSKPSLASPY LPEGTSKPLS DRPTKAPVYM PHPETPSKPS PCLVGEASKP
   541  PAPSEGSPKA VASSPAATNS EVKMTSFAER KKQLVKAEAE AGAGSPTSTP APPEALSSEM
   601  SELSARLEEK RRAIEAQKRR IEAIFAKHRQ RLGKSAFLQV QPREASGEAE AEAEEADSGP
   661  VPGGERPAGE GQGEPTSRPK AVTFSPDLGP VPHEGLGEYN RAVSKLSAAL SSLQRDMQRL
   721  TDQQQRLLAP PEAPGSAPPP AAWVIPGPTT GPKAASPSPA RRVPATRRSP GPGPSQSPRS
   781  PKHTRPAELR LAPLTRVLTP PHDVDSLPHL RKFSPSQVPV QTRSSILLAE ETPPEEPAAR
   841  PGLIEIPLGS LADPAAEDEG DGSPAGAEDS LEEEASSEGE PRVGLGFFYK DEDKPEDEMA
   901  QKRASLLERQ QRRAEEARRR KQWQEVEKEQ RREEAARLAQ EEAPGPAPLV SAVPMATPAP
   961  AARAPAEEEV GPRKGDFTRQ EYERRAQLKL MDDLDKVLRP RAAGSGGPGR GGRRATRPRS
  1021  GCCDDSALAR SPARGLLGSR LSKIYSQSTL SLSTVANEAH NNLGVKRPTS RAPSPSGLMS
  1081  PSRLPGSRER DWENGSNASS PASVPEYTGP RLYKEPSAKS NKFIIHNALS HCCLAGKVNE
  1141  PQKNRILEEI EKSKANHFLI LFRDSSCQFR ALYTLSGETE ELSRLAGYGP RTVTPAMVEG
  1201  IYKYNSDRKR FTQIPAKTMS MSVDAFTIQG HLWQGKKPTT PKKGGGTPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMSAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • skin: 60 nTPM
  • esophagus: 24 nTPM
  • liver: 24 nTPM
  • pancreas: 20 nTPM
  • cerebellum: 18 nTPM
  • salivary gland: 17 nTPM

Single-cell type

  • esophageal apical cells: 126 nCPM
  • breast lactating cells: 84 nCPM
  • sertoli cells: 55 nCPM
  • lacrimal acinar cells: 54 nCPM
  • foveolar cells: 54 nCPM
  • colonocytes: 44 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • hippocampal formation: 27 nTPM
  • basal ganglia: 25 nTPM
  • cerebellum: 24 nTPM
  • white matter: 24 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
3.35
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMSAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMSAP3 as an antibody target. Whether an autoantibody or antibody against CAMSAP3 could matter depends on whether native CAMSAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMSAP3 is annotated at the cell surface, where native CAMSAP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CAMSAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAMSAP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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