Seroatlas · Human Serome Atlas

RIPOR2

Rho family-interacting cell polarization regulator 2

Also known as: C6orf32, DIFF48, FAM65B, KIAA0386, MYONAP, RIPR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4F9
Gene
RIPOR2
Ensembl
ENSG00000111913
Chromosome
6
Canonical length
1068 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

1068 residues, UniProt reviewed canonical sequence.

>Q9Y4F9|RIPOR2
     1  MLVGSQSFSP GGPNGIIRSQ SFAGFSGLQE RRSRCNSFIE NSSALKKPQA KLKKMHNLGH
    61  KNNNPPKEPQ PKRVEEVYRA LKNGLDEYLE VHQTELDKLT AQLKDMKRNS RLGVLYDLDK
   121  QIKTIERYMR RLEFHISKVD ELYEAYCIQR RLQDGASKMK QAFATSPASK AARESLTEIN
   181  RSFKEYTENM CTIEVELENL LGEFSIKMKG LAGFARLCPG DQYEIFMKYG RQRWKLKGKI
   241  EVNGKQSWDG EETVFLPLIV GFISIKVTEL KGLATHILVG SVTCETKELF AARPQVVAVD
   301  INDLGTIKLN LEITWYPFDV EDMTASSGAG NKAAALQRRM SMYSQGTPET PTFKDHSFFR
   361  WLHPSPDKPR RLSVLSALQD TFFAKLHRSR SFSDLPSLRP SPKAVLELYS NLPDDIFENG
   421  KAAEEKMPLS LSFSDLPNGD CALTSHSTGS PSNSTNPEIT ITPAEFNLSS LASQNEGMDD
   481  TSSASSRNSL GEGQEPKSHL KEEDPEEPRK PASAPSEACR RQSSGAGAEH LFLENDVAEA
   541  LLQESEEASE LKPVELDTSE GNITKQLVKR LTSAEVPMAT DRLLSEGSVG GESEGCRSFL
   601  DGSLEDAFNG LLLALEPHKE QYKEFQDLNQ EVMNLDDILK CKPAVSRSRS SSLSLTVESA
   661  LESFDFLNTS DFDEEEDGDE VCNVGGGADS VFSDTETEKH SYRSVHPEAR GHLSEALTED
   721  TGVGTSVAGS PLPLTTGNES LDITIVRHLQ YCTQLVQQIV FSSKTPFVAR SLLEKLSRQI
   781  QVMEKLAAVS DENIGNISSV VEAIPEFHKK LSLLSFWTKC CSPVGVYHSP ADRVMKQLEA
   841  SFARTVNKEY PGLADPVFRT LVSQILDRAE PLLSSSLSSE VVTVFQYYSY FTSHGVSDLE
   901  SYLSQLARQV SMVQTLQSLR DEKLLQTMSD LAPSNLLAQQ EVLRTLALLL TREDNEVSEA
   961  VTLYLAAASK NQHFREKALL YYCEALTKTN LQLQKAACLA LKILEATESI KMLVTLCQSD
  1021  TEEIRNVASE TLLSLGEDGR LAYEQLDKFP RDCVKVGGRH GTEVATAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 77 nTPM
  • tonsil: 67 nTPM
  • spleen: 53 nTPM
  • endometrium: 49 nTPM
  • appendix: 46 nTPM
  • thymus: 38 nTPM

Single-cell type

  • neutrophils: 7,917 nCPM
  • platelets: 2,771 nCPM
  • hematopoietic stem cells: 1,117 nCPM
  • b-cells: 875 nCPM
  • thymocytes: 750 nCPM
  • neutrophil progenitors: 719 nCPM

Immune cell

  • neutrophil: 956 nTPM
  • basophil: 415 nTPM
  • eosinophil: 335 nTPM
  • memory B-cell: 189 nTPM
  • naive B-cell: 177 nTPM
  • non-classical monocyte: 175 nTPM

Brain region

  • basal ganglia: 58 nTPM
  • cerebral cortex: 47 nTPM
  • hippocampal formation: 35 nTPM
  • midbrain: 33 nTPM
  • hypothalamus: 32 nTPM
  • amygdala: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RIPOR2.

Disease | AllUniProt

Conditions RIPOR2 is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 104 (DFNB104) MIM:616515
  • Deafness, autosomal dominant, 21 (DFNA21) MIM:607017

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 528 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal recessive nonsyndromic hearing loss 104

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.92
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPOR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPOR2 as an antibody target. Whether an autoantibody or antibody against RIPOR2 could matter depends on whether native RIPOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPOR2 is annotated at the cell surface, where native RIPOR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIPOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIPOR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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