Seroatlas · Human Serome Atlas

TBC1D22B

TBC1 domain family member 22B

Also known as: C6orf197, dJ744I24.2, FLJ20337, TB22B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NU19
Gene: TBC1D22B
Ensembl: ENSG00000065491
Chromosome: 6
Canonical length: 505 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables 14-3-3 protein binding activity. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9NU19|TBC1D22B
     1  MAAENSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVNTVP LKNKKASSFH
    61  EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV LENHSKLRVK PERSQSTTSD
   121  VPANYKVIKS SSDAQLSRNS SDTCLRNPLH KQQSLPLRPI IPLVARISDQ NASGAPPMTV
   181  REKTRLEKFR QLLSSQNTDL DELRKCSWPG VPREVRPITW RLLSGYLPAN TERRKLTLQR
   241  KREEYFGFIE QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI
   301  RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD SFWCMSKLLD
   361  GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV EYLQFAFRWM NNLLMRELPL
   421  RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE
   481  EIGLLLAEAY RLKYMFADAP NHYRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D22B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
skin: 15 nTPM
skeletal muscle: 14 nTPM
esophagus: 14 nTPM
thymus: 13 nTPM
pancreas: 12 nTPM

Single-cell type

epicardial cells: 123 nCPM
neutrophil progenitors: 100 nCPM
esophageal apical cells: 98 nCPM
myonuclei: 88 nCPM
salivary acinar cells: 88 nCPM
urothelial cells: 79 nCPM

Immune cell

eosinophil: 4.4 nTPM
myeloid DC: 4 nTPM
intermediate monocyte: 3.5 nTPM
NK-cell: 3 nTPM
naive CD4 T-cell: 2.8 nTPM
MAIT T-cell: 2.7 nTPM

Brain region

choroid plexus: 12 nTPM
thalamus: 12 nTPM
hypothalamus: 12 nTPM
basal ganglia: 11 nTPM
cerebellum: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.03
gnomAD missense Z: 2.42
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D22B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D22B as an antibody target. Whether an autoantibody or antibody against TBC1D22B could matter depends on whether native TBC1D22B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D22B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D22B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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