Seroatlas · Human Serome Atlas

CRTC1

CREB-regulated transcription coactivator 1

Also known as: CRTC1_HUMAN, FLJ14027, KIAA0616, MECT1, TORC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UUV9
Gene
CRTC1
Ensembl
ENSG00000105662
Chromosome
19
Canonical length
634 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q6UUV9|CRTC1
     1  MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY
    61  YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS
   121  VDKHGRQADS CPYGTMYLSP PADTSWRRTN SDSALHQSTM TPTQPESFSS GSQDVHQKRV
   181  LLLTVPGMEE TTSEADKNLS KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH
   241  NTGGSLPDLT NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP
   301  GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL PYAFFTQAGS
   361  QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP SASLTRGPQP PPLAVTVPSS
   421  LPQSPPENPG QPSMGIDIAS APALQQYRTS AGSPANQSPT SPVSNQGFSP GSSPQHTSTL
   481  GSVFGDAYYE QQMAARQANA LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS
   541  HGSLPDSQQL GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL
   601  KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRTC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 72 nTPM
  • cerebral cortex: 45 nTPM
  • basal ganglia: 35 nTPM
  • amygdala: 31 nTPM
  • hippocampal formation: 28 nTPM
  • pituitary gland: 21 nTPM

Single-cell type

  • retinal amacrine cells: 150 nCPM
  • renal collecting duct intercalated cells: 131 nCPM
  • somatotrophs: 113 nCPM
  • lactotrophs: 107 nCPM
  • retinal horizontal cells: 104 nCPM
  • thyrotrophs: 103 nCPM

Immune cell

  • plasmacytoid DC: 0.8 nTPM
  • myeloid DC: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • classical monocyte: 0.6 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • memory B-cell: 0.5 nTPM

Brain region

  • cerebellum: 139 nTPM
  • hippocampal formation: 126 nTPM
  • cerebral cortex: 121 nTPM
  • amygdala: 112 nTPM
  • basal ganglia: 105 nTPM
  • white matter: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.53
gnomAD missense Z
2.33
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRTC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRTC1 as an antibody target. Whether an autoantibody or antibody against CRTC1 could matter depends on whether native CRTC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRTC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRTC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRTC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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