Seroatlas · Human Serome Atlas

PI4KB

Phosphatidylinositol 4-kinase beta

Also known as: PI4K-BETA, pi4K92, PI4KB_HUMAN, PIK4CB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBF8
Gene
PI4KB
Ensembl
ENSG00000143393
Chromosome
1
Canonical length
816 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Involved in inner ear development. Acts upstream of or within lysosome organization. Located in Golgi membrane. Implicated in autosomal dominant nonsyndromic deafness 87. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

816 residues, UniProt reviewed canonical sequence.

>Q9UBF8|PI4KB
     1  MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK ACQEVLEKVK
    61  LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE EDEMGAAVAS GTAKGARRRR
   121  QNNSAKQSWL LRLFESKLFD ISMAISYLYN SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL
   181  NMYIHMDEDV GDAIKPYIVH RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI
   241  LSDELKPAHR KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
   301  EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ RLISELSLLN
   361  HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY VEVLECENFD TTSVPARIPE
   421  NRIRSTRSVE NLPECGITHE QRAGSFSTVP NYDNDDEAWS VDDIGELQVE LPEVHTNSCD
   481  NISQFSVDSI TSQESKEPVF IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK
   541  VRRIREGSPY GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
   601  LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ RNFVQSCAGY
   661  CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN LGFETSAFKL TTEFVDVMGG
   721  LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI VEIMQQGSQL PCFHGSSTIR NLKERFHMSM
   781  TEEQLQLLVE QMVDGSMRSI TTKLYDGFQY LTNGIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PI4KB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 74 nTPM
  • skeletal muscle: 65 nTPM
  • thyroid gland: 65 nTPM
  • cerebellum: 64 nTPM
  • fallopian tube: 61 nTPM
  • endometrium: 59 nTPM

Single-cell type

  • syncytiotrophoblasts: 108 nCPM
  • urothelial cells: 101 nCPM
  • esophageal apical cells: 79 nCPM
  • hofbauer cells: 68 nCPM
  • choroid plexus epithelial cells: 65 nCPM
  • monocytes: 62 nCPM

Immune cell

  • basophil: 41 nTPM
  • eosinophil: 36 nTPM
  • non-classical monocyte: 26 nTPM
  • intermediate monocyte: 24 nTPM
  • myeloid DC: 24 nTPM
  • total PBMC: 24 nTPM

Brain region

  • white matter: 89 nTPM
  • cerebellum: 85 nTPM
  • cerebral cortex: 80 nTPM
  • hypothalamus: 80 nTPM
  • pons: 78 nTPM
  • midbrain: 77 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PI4KB.

Disease | AllUniProt

Conditions PI4KB is implicated in, by any mechanism.

  • Deafness, autosomal dominant, 87 (DFNA87) MIM:620281

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hearing loss, autosomal dominant 87

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.87
gnomAD missense Z
3.55
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PI4KB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PI4KB as an antibody target. Whether an autoantibody or antibody against PI4KB could matter depends on whether native PI4KB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PI4KB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PI4KB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PI4KB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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