Seroatlas · Human Serome Atlas

GAB2

GRB2-associated-binding protein 2

Also known as: GAB2_HUMAN, KIAA0571

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQC2
Gene: GAB2
Ensembl: ENSG00000033327
Chromosome: 11
Canonical length: 676 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>Q9UQC2|GAB2
     1  MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK NDHSKKPLRI
    61  INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE TEEDMNKWVQ SICQICGFNQ
   121  AEESTDSLRN VSSAGHGPRS SPAELSSSSQ HLLRERKSSA PSHSSQPTLF TFEPPVSNHM
   181  QPTLSTSAPQ EYLYLHQCIS RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG
   241  ISGQVHGFYS LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN
   301  TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA PPPRPPKPSQ
   361  AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL HRASSCETYE YPQRGGESAG
   421  RSAESMSDGV GSFLPGKMIV GRSDSTNSED NYVPMNPGSS TLLAMERAGD NSQSVYIPMS
   481  PGAHHFDSLG YPSTTLPVHR GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP
   541  FKSPITKSWS RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT
   601  NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK TQALQNTMQE
   661  WTDVRQSSEP SKGAKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 54 nTPM
midbrain: 49 nTPM
amygdala: 44 nTPM
hippocampal formation: 43 nTPM
basal ganglia: 41 nTPM
bone marrow: 38 nTPM

Single-cell type

neutrophils: 3,649 nCPM
monocytes: 1,009 nCPM
microglia: 775 nCPM
thymocytes: 727 nCPM
oligodendrocytes: 609 nCPM
macrophages: 545 nCPM

Immune cell

neutrophil: 20 nTPM
basophil: 13 nTPM
non-classical monocyte: 4.9 nTPM
classical monocyte: 3.1 nTPM
plasmacytoid DC: 2.2 nTPM
intermediate monocyte: 1.7 nTPM

Brain region

white matter: 174 nTPM
medulla oblongata: 139 nTPM
basal ganglia: 139 nTPM
thalamus: 121 nTPM
midbrain: 120 nTPM
amygdala: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: -0.62
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAB2 as an antibody target. Whether an autoantibody or antibody against GAB2 could matter depends on whether native GAB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAB2 is annotated at the cell surface, where native GAB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GAB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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