Seroatlas · Human Serome Atlas

BLTP3B

Bridge-like lipid transfer protein family member 3B

Also known as: BLT3B_HUMAN, KIAA0701, SHIP164, UHRF1BP1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0JNW5
Gene
BLTP3B
Ensembl
ENSG00000111647
Chromosome
12
Canonical length
1464 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables GARP complex binding activity; lipid transfer activity; and protein homodimerization activity. Involved in early endosome to Golgi transport and intermembrane lipid transfer. Located in cytosol and early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1464 residues, UniProt reviewed canonical sequence.

>A0JNW5|BLTP3B
     1  MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGELKNLE LDEEVLQNML DLPTWLAINK
    61  VFCNKASIRI PWTKLKTHPI CLSLDKVIME MSTCEEPRSP NGPSPIATAS GQSEYGFAEK
   121  VVEGISVSVN SIVIRIGAKA FNASFELSQL RIYSVNAHWE HGDLRFTRIQ DPQRGEVLTF
   181  KEINWQMIRI EADATQSSHL EIMCAPVRLI TNQSKIRVTL KRRLKDCNVI ATKLVLILDD
   241  LLWVLTDSQL KAMVQYAKSL SEAIEKSTEQ RKSMAPEPTQ SSTVVASAQQ VKTTQTSNAP
   301  DVNDAIVKLF NDFDVKETSH HLVISHLDLH ICDDIHAKEK ESNRRITGGA MQLSFTQLTI
   361  DYYPYHKAGD SCNHWMYFSD ATKTKNGWAN ELLHEFECNV EMLKQAVKDH NVGSPPKSPT
   421  HASPQHTQTE KDYPLKGTCR TPSVLSQQSK AKLMSSSVVV RLADFNIYQV STAEQCRSSP
   481  KSMICCNKKS LYLPQEMSAV YIEFTEYYYP DGKDFPIPSP NLYSQLNALQ FTVDERSILW
   541  LNQFLLDLKQ SLNQFMAVYK LNDNSKSDEH VDVRVDGLML KFVIPSEVKS ECHQDQPRAI
   601  SIQSSEMIAT NTRHCPNCRH SDLEALFQDF KDCDFFSKTY TSFPKSCDNF NLLHPIFQRH
   661  AHEQDTKMHE IYKGNITPQL NKNTLKTSAA TDVWAVYFSQ FWIDYEGMKS GKGRPISFVD
   721  SFPLSIWICQ PTRYAESQKE PQTCNQVSLN TSQSESSDLA GRLKRKKLLK EYYSTESEPL
   781  TNGGQKPSSS DTFFRFSPSS SEADIHLLVH VHKHVSMQIN HYQYLLLLFL HESLILLSEN
   841  LRKDVEAVTG SPASQTSICI GILLRSAELA LLLHPVDQAN TLKSPVSESV SPVVPDYLPT
   901  ENGDFLSSKR KQISRDINRI RSVTVNHMSD NRSMSVDLSH IPLKDPLLFK SASDTNLQKG
   961  ISFMDYLSDK HLGKISEDES SGLVYKSGSG EIGSETSDKK DSFYTDSSSI LNYREDSNIL
  1021  SFDSDGNQNI LSSTLTSKGN ETIESIFKAE DLLPEAASLS ENLDISKEET PPVRTLKSQS
  1081  SLSGKPKERC PPNLAPLCVS YKNMKRSSSQ MSLDTISLDS MILEEQLLES DGSDSHMFLE
  1141  KGNKKNSTTN YRGTAESVNA GANLQNYGET SPDAISTNSE GAQENHDDLM SVVVFKITGV
  1201  NGEIDIRGED TEICLQVNQV TPDQLGNISL RHYLCNRPVG SDQKAVIHSK SSPEISLRFE
  1261  SGPGAVIHSL LAEKNGFLQC HIENFSTEFL TSSLMNIQHF LEDETVATVM PMKIQVSNTK
  1321  INLKDDSPRS STVSLEPAPV TVHIDHLVVE RSDDGSFHIR DSHMLNTGND LKENVKSDSV
  1381  LLTSGKYDLK KQRSVTQATQ TSPGVPWPSQ SANFPEFSFD FTREQLMEEN ESLKQELAKA
  1441  KMALAEAHLE KDALLHHIKK MTVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLTP3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 31 nTPM
  • liver: 23 nTPM
  • skeletal muscle: 19 nTPM
  • cerebral cortex: 19 nTPM
  • tongue: 14 nTPM
  • retina: 14 nTPM

Single-cell type

  • neutrophils: 482 nCPM
  • neutrophil progenitors: 143 nCPM
  • microglia: 136 nCPM
  • monocytes: 121 nCPM
  • fibro-adipogenic progenitors: 101 nCPM
  • monocyte progenitors: 99 nCPM

Immune cell

  • neutrophil: 34 nTPM
  • basophil: 22 nTPM
  • myeloid DC: 13 nTPM
  • intermediate monocyte: 12 nTPM
  • classical monocyte: 11 nTPM
  • non-classical monocyte: 11 nTPM

Brain region

  • hippocampal formation: 46 nTPM
  • cerebral cortex: 44 nTPM
  • cerebellum: 41 nTPM
  • choroid plexus: 40 nTPM
  • white matter: 37 nTPM
  • basal ganglia: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BLTP3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLTP3B as an antibody target. Whether an autoantibody or antibody against BLTP3B could matter depends on whether native BLTP3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLTP3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BLTP3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BLTP3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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