Seroatlas · Human Serome Atlas

USP7

Ubiquitin carboxyl-terminal hydrolase 7

Also known as: HAUSP, UBP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93009
Gene: USP7
Ensembl: ENSG00000187555
Chromosome: 16
Canonical length: 1102 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

1102 residues, UniProt reviewed canonical sequence.

>Q93009|USP7
     1  MNHQQQQQQQ KAGEQQLSEP EDMEMEAGDT DDPPRITQNP VINGNVALSD GHNTAEEDME
    61  DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP HQKSVGFFLQ
   121  CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE
   181  KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK
   241  AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC
   301  RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI QLSIKGKKNI
   361  FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK
   421  INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF
   481  DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA VTDHDIPQQL
   541  VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS
   601  SLAEFVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI
   661  FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM
   721  CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDNSEL
   781  PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF
   841  KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCIWLN
   901  SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII GVHQEDELLE
   961  CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR IHQGEHFREV
  1021  MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM SHPRPWLGLD
  1081  HFNKAPKRSR YTYLEKAIKI HN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
bone marrow: 51 nTPM
thymus: 48 nTPM
skeletal muscle: 42 nTPM
tonsil: 42 nTPM
tongue: 38 nTPM

Single-cell type

early spermatids: 333 nCPM
late primary spermatocytes: 178 nCPM
neutrophils: 163 nCPM
late spermatids: 143 nCPM
monocyte progenitors: 138 nCPM
neutrophil progenitors: 137 nCPM

Immune cell

plasmacytoid DC: 6.5 nTPM
non-classical monocyte: 6.1 nTPM
MAIT T-cell: 5.7 nTPM
memory CD8 T-cell: 5.3 nTPM
basophil: 5.2 nTPM
T-reg: 5.1 nTPM

Brain region

cerebral cortex: 43 nTPM
hippocampal formation: 43 nTPM
midbrain: 43 nTPM
white matter: 42 nTPM
cerebellum: 41 nTPM
basal ganglia: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USP7.

Disease | AllUniProt

Conditions USP7 is implicated in, by any mechanism.

Hao-Fountain syndrome (HAFOUS) MIM:616863

Disease | GeneticClinVar

53 pathogenic / likely-pathogenic of 606 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hao-Fountain syndrome
Hao-Fountain syndrome due to USP7 mutation
Inborn genetic diseases
USP7-related disorder
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.06
gnomAD pLI: 1
gnomAD missense Z: 5.65
DepMap mean gene effect: -0.82
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase C19, ubiquitin carboxyl-terminal hydrolase
MATH/TRAF domain
TRAF-like
Ubiquitin specific protease, conserved site
Ubiquitin specific protease UPS, catalytic domain
Ubiquitin carboxyl-terminal hydrolase, C-terminal
Papain-like cysteine peptidase superfamily
Ubiquitin carboxyl-terminal hydrolases
Ubiquitin carboxyl-terminal hydrolase
Ubiquitin-specific protease C-terminal
MATH domain
Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
ICP0-binding domain of Ubiquitin-specific protease 7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP7 as an antibody target. Whether an autoantibody or antibody against USP7 could matter depends on whether native USP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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