Seroatlas · Human Serome Atlas

ABRAXAS2

BRISC complex subunit Abraxas 2

Also known as: ABRO1, ABRX2_HUMAN, Em:AC068896.4, FAM175B, KIAA0157

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15018
Gene
ABRAXAS2
Ensembl
ENSG00000165660
Chromosome
10
Canonical length
415 aa
Protein class
Predicted intracellular proteins
Subcellular location
Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in nuclear chromosome segregation; protein K63-linked deubiquitination; and response to ischemia. Located in cytosol; microtubule cytoskeleton; and midbody. Part of BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q15018|ABRAXAS2
     1  MAASISGYTF SAVCFHSANS NADHEGFLLG EVRQEETFSI SDSQISNTEF LQVIEIHNHQ
    61  PCSKLFSFYD YASKVNEESL DRILKDRRKK VIGWYRFRRN TQQQMSYREQ VLHKQLTRIL
   121  GVPDLVFLLF SFISTANNST HALEYVLFRP NRRYNQRISL AIPNLGNTSQ QEYKVSSVPN
   181  TSQSYAKVIK EHGTDFFDKD GVMKDIRAIY QVYNALQEKV QAVCADVEKS ERVVESCQAE
   241  VNKLRRQITQ RKNEKEQERR LQQAVLSRQM PSESLDPAFS PRMPSSGFAA EGRSTLGDAE
   301  ASDPPPPYSD FHPNNQESTL SHSRMERSVF MPRPQAVGSS NYASTSAGLK YPGSGADLPP
   361  PQRAAGDSGE DSDDSDYENL IDPTEPSNSE YSHSKDSRPM AHPDEDPRNT QTSQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABRAXAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 18 nTPM
  • tongue: 15 nTPM
  • liver: 13 nTPM
  • tonsil: 13 nTPM
  • parathyroid gland: 12 nTPM
  • thymus: 12 nTPM

Single-cell type

  • myonuclei: 51 nCPM
  • oocytes: 37 nCPM
  • thymic myoid cells: 37 nCPM
  • esophageal apical cells: 36 nCPM
  • retinal pigment epithelial cells: 34 nCPM
  • neutrophil progenitors: 31 nCPM

Immune cell

  • basophil: 23 nTPM
  • intermediate monocyte: 15 nTPM
  • myeloid DC: 13 nTPM
  • non-classical monocyte: 12 nTPM
  • naive B-cell: 12 nTPM
  • T-reg: 11 nTPM

Brain region

  • hypothalamus: 13 nTPM
  • pons: 13 nTPM
  • cerebral cortex: 13 nTPM
  • midbrain: 13 nTPM
  • basal ganglia: 12 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.02
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABRAXAS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABRAXAS2 as an antibody target. Whether an autoantibody or antibody against ABRAXAS2 could matter depends on whether native ABRAXAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABRAXAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABRAXAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABRAXAS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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