Seroatlas · Human Serome Atlas

OTUD4

OTU domain-containing protein 4

Also known as: DUBA6, HSHIN1, KIAA1046, OTUD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01804
Gene: OTUD4
Ensembl: ENSG00000164164
Chromosome: 4
Canonical length: 1114 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

1114 residues, UniProt reviewed canonical sequence.

>Q01804|OTUD4
     1  MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR
    61  HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY
   121  REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD
   181  VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS
   241  LPLSRKVLKS LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF
   301  LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST SGQNFHSDVD
   361  YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ SQKFSSEHKN LSRTPSQIIR
   421  KPDRERVEDF DHTSRESNYF GLSPEERREK QAIEESRLLY EIQNRDEQAF PALSSSSVNQ
   481  SASQSSNPCV QRKSSHVGDR KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK
   541  YATVSSPSKS KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE
   601  PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP LMPLPQTLSL
   661  YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR FFFNLGVKAY SCPMWAPHSY
   721  LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ EAPAAQNESD CTCTDAHFPM QTEASVNGQM
   781  PQPEIGPPTF SSPLVIPPSQ VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP
   841  SFGPNPFLGP VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS
   901  KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL ASIPPVAEGK
   961  AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT AADVVSPGAN SVDSRVQRPK
  1021  EESSEDENEV SNILRSGRSK QFYNQTYGSR KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS
  1081  RDEGYQYHRN VRGRPFRGDR RRSGMGDGHR GQHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
tongue: 38 nTPM
bone marrow: 30 nTPM
testis: 30 nTPM
liver: 19 nTPM
urinary bladder: 17 nTPM

Single-cell type

early spermatids: 241 nCPM
epicardial cells: 173 nCPM
myonuclei: 159 nCPM
endometrial ciliated cells: 119 nCPM
epididymal basal cells: 113 nCPM
late spermatids: 111 nCPM

Immune cell

gdT-cell: 0.9 nTPM
eosinophil: 0.8 nTPM
memory B-cell: 0.8 nTPM
non-classical monocyte: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
plasmacytoid DC: 0.7 nTPM

Brain region

white matter: 39 nTPM
cerebellum: 36 nTPM
basal ganglia: 34 nTPM
choroid plexus: 32 nTPM
cerebral cortex: 30 nTPM
thalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OTUD4.

Disease | ImmuneIEDB

Conditions an epitope on OTUD4 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

antiviral innate immune response
DNA alkylation repair
negative regulation of interleukin-1-mediated signaling pathway
negative regulation of toll-like receptor signaling pathway
protein K11-linked deubiquitination
protein K48-linked deubiquitination
protein K63-linked deubiquitination
proteolysis
regulation of protein K48-linked deubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTUD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUD4 as an antibody target. Whether an autoantibody or antibody against OTUD4 could matter depends on whether native OTUD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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