Seroatlas · Human Serome Atlas

MAGEE1

Melanoma-associated antigen E1

Also known as: DAMAGE, KIAA1587, MAGE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCI5
Gene
MAGEE1
Ensembl
ENSG00000198934
Chromosome
X
Canonical length
957 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytokinetic bridge,Cytosol

OverviewNCBI Gene

This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

957 residues, UniProt reviewed canonical sequence.

>Q9HCI5|MAGEE1
     1  MSLVSQNSRR RRRRVAKATA HNSSWGEMQA PNAPGLPADV PGSDVPQGPS DSQILQGLCA
    61  SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTISEGP GTSVLPTPSE GLSTSGPPTI
   121  SKGLCTSVTL AASEGRNTSR PPTSSEEPST SVPPTASEVP STSLPPTPGE GTSTSVPPTA
   181  YEGPSTSVVP TPDEGPSTSV LPTPGEGPGT SVPLAATEGL STSVQATPDE GPSTSVPPTA
   241  TEGLSTPVPP TRDEGPSTSV PATPGEGPST SVLPAASDGQ SISLVPTRGK GSSTSVPPTA
   301  TEGLSTSVQP TAGEGSSTSV PPTPGGGLST SVPPTATEEL STSVPPTPGE GPSTSVLPIP
   361  GEGLSTSVPP TASDGSDTSV PPTPGEGAST LVQPTAPDGP GSSVLPNPGE GPSTLFSSSA
   421  SVDRNPSKCS LVLPSPRVTK ASVDSDSEGP KGAEGPIEFE VLRDCESPNS ISIMGLNTSR
   481  VAITLKPQDP MEQNVAELLQ FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL
   541  ECIFRFELRE LDPEAHTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE
   601  AEIWEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE YEFFWGPRSH
   661  LETTKMKILK FMAKIYNKDP MDWPEKYNEA LEEDAARAFA EGWQALPHFR RPFFEEAAAE
   721  VPSPDSEVSS YSSKYAPHSW PESRLESKAR KLVQLFLLMD STKLPIPKKG ILYYIGRECS
   781  KVFPDLLNRA ARTLNHVYGT ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ
   841  VLSFIFIMGN HARESAVWAF LRGLGVQAGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV
   901  WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ IFVHNFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 25 nTPM
  • hypothalamus: 21 nTPM
  • cerebellum: 21 nTPM
  • basal ganglia: 18 nTPM
  • hippocampal formation: 12 nTPM
  • amygdala: 11 nTPM

Single-cell type

  • adrenal medulla cells: 32 nCPM
  • other brain neurons: 24 nCPM
  • brain excitatory neurons: 16 nCPM
  • brain inhibitory neurons: 16 nCPM
  • corticotrophs: 10 nCPM
  • retinal amacrine cells: 8 nCPM

Immune cell

  • gdT-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 71 nTPM
  • hypothalamus: 65 nTPM
  • basal ganglia: 49 nTPM
  • pons: 46 nTPM
  • hippocampal formation: 42 nTPM
  • white matter: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
1.44
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAGEE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEE1 as an antibody target. Whether an autoantibody or antibody against MAGEE1 could matter depends on whether native MAGEE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEE1 is annotated at the cell surface, where native MAGEE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAGEE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAGEE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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