Seroatlas · Human Serome Atlas

CRY2

Cryptochrome-2

Also known as: CRY2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q49AN0
Gene
CRY2
Ensembl
ENSG00000121671
Chromosome
11
Canonical length
593 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q49AN0|CRY2
     1  MAATVATAAA VAPAPAPGTD SASSVHWFRK GLRLHDNPAL LAAVRGARCV RCVYILDPWF
    61  AASSSVGINR WRFLLQSLED LDTSLRKLNS RLFVVRGQPA DVFPRLFKEW GVTRLTFEYD
   121  SEPFGKERDA AIMKMAKEAG VEVVTENSHT LYDLDRIIEL NGQKPPLTYK RFQAIISRME
   181  LPKKPVGLVT SQQMESCRAE IQENHDETYG VPSLEELGFP TEGLGPAVWQ GGETEALARL
   241  DKHLERKAWV ANYERPRMNA NSLLASPTGL SPYLRFGCLS CRLFYYRLWD LYKKVKRNST
   301  PPLSLFGQLL WREFFYTAAT NNPRFDRMEG NPICIQIPWD RNPEALAKWA EGKTGFPWID
   361  AIMTQLRQEG WIHHLARHAV ACFLTRGDLW VSWESGVRVF DELLLDADFS VNAGSWMWLS
   421  CSAFFQQFFH CYCPVGFGRR TDPSGDYIRR YLPKLKAFPS RYIYEPWNAP ESIQKAAKCI
   481  IGVDYPRPIV NHAETSRLNI ERMKQIYQQL SRYRGLCLLA SVPSCVEDLS HPVAEPSSSQ
   541  AGSMSSAGPR PLPSGPASPK RKLEAAEEPP GEELSKRARV AELPTPELPS KDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 91 nTPM
  • liver: 62 nTPM
  • tongue: 60 nTPM
  • heart muscle: 56 nTPM
  • cerebellum: 53 nTPM
  • retina: 49 nTPM

Single-cell type

  • retinal bipolar cells: 224 nCPM
  • retinal amacrine cells: 215 nCPM
  • retinal ganglion cells: 174 nCPM
  • retinal horizontal cells: 142 nCPM
  • respiratory ciliated cells: 132 nCPM
  • cone photoreceptor cells: 126 nCPM

Immune cell

  • non-classical monocyte: 8.1 nTPM
  • NK-cell: 7.6 nTPM
  • naive CD8 T-cell: 6.9 nTPM
  • naive CD4 T-cell: 6.6 nTPM
  • memory CD8 T-cell: 6.1 nTPM
  • gdT-cell: 5.7 nTPM

Brain region

  • hippocampal formation: 56 nTPM
  • cerebellum: 55 nTPM
  • cerebral cortex: 55 nTPM
  • thalamus: 54 nTPM
  • basal ganglia: 52 nTPM
  • amygdala: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
2.06
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRY2 as an antibody target. Whether an autoantibody or antibody against CRY2 could matter depends on whether native CRY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRY2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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