Seroatlas · Human Serome Atlas

PHLDB2

Pleckstrin homology-like domain family B member 2

Also known as: FLJ21791, LL5b, LL5beta, PHLB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SQ0
Gene: PHLDB2
Ensembl: ENSG00000144824
Chromosome: 3
Canonical length: 1253 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cytoskeleton; and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1253 residues, UniProt reviewed canonical sequence.

>Q86SQ0|PHLDB2
     1  MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK ANGDYSGSYL
    61  TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD KNIPMKPPTP LLNTTSSLSG
   121  YPLGRADFDH YTGRDSERAL RLSEKPPYSK YSSRHKSHDN VYSLGGLEGR KASGSLLAMW
   181  NGSSLSDAGP PPISRSGAAS MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK
   241  YSSSSLSHMG AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN
   301  YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA SDDFDQASYV
   361  GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ ASGTPQPALR ERKSSISSIS
   421  GRDDLMDYHR RQREERLREQ EMERLERQRL ETILSLCAEY TKPDSRLSTG TTVEDVQKIN
   481  KELEKLQLSD EESVFEEALM SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN
   541  DELLSDLTRT PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN
   601  LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL NRKIAELEKN
   661  IVGEKTKEKV KLDAEREKLE RLQELYSEQK TQLDNCPESM REQLQQQLKR DADLLDVESK
   721  HFEDLEFQQL EHESRLDEEK ENLTQQLLRE VAEYQRNIVS RKEKISALKK QANHIVQQAQ
   781  REQDHFVKEK NNLIMMLQRE KENLCNLEKK YSSLSGGKGF PVNPNTLKEG YISVNEINEP
   841  CGNSTNLSPS TQFPADADAV ATEPATAVLA SQPQSKEHFR SLEERKKQHK EGLYLSDTLP
   901  RKKTTSSISP HFSSATMGRS ITPKAHLPLG QSNSCGSVLP PSLAAMAKDS ESRRMLRGYN
   961  HQQMSEGHRQ KSEFYNRTAS ESNVYLNSFH YPDHSYKDQA FDTLSLDSSD SMETSISACS
  1021  PDNISSASTS NIARIEEMER LLKQAHAEKT RLLESREREM EAKKRALEEE KRRREILEKR
  1081  LQEETSQRQK LIEKEVKIRE RQRAQARPLT RYLPVRKEDF DLRSHVETAG HNIDTCYHVS
  1141  ITEKTCRGFL IKMGGKIKTW KKRWFVFDRN KRTFSYYADK HETKLKGVIY FQAIEEVYYD
  1201  HLKNANKSPN PLLTFSVKTH DRIYYMVAPS PEAMRIWMDV IVTGAEGYTH FLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHLDB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 40 nTPM
placenta: 38 nTPM
blood vessel: 37 nTPM
liver: 33 nTPM
kidney: 30 nTPM
colon: 26 nTPM

Single-cell type

epicardial cells: 1,133 nCPM
salivary ionocytes: 693 nCPM
ocular epithelial cells: 669 nCPM
basal keratinocytes: 656 nCPM
salivary basal cells: 480 nCPM
adipocytes: 464 nCPM

Immune cell

memory CD8 T-cell: 2.9 nTPM
gdT-cell: 2.6 nTPM
MAIT T-cell: 1.8 nTPM
memory CD4 T-cell: 1.8 nTPM
naive CD8 T-cell: 1.1 nTPM
NK-cell: 1 nTPM

Brain region

choroid plexus: 26 nTPM
cerebral cortex: 13 nTPM
thalamus: 13 nTPM
basal ganglia: 10 nTPM
amygdala: 9.5 nTPM
white matter: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cadherin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHLDB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHLDB2 as an antibody target. Whether an autoantibody or antibody against PHLDB2 could matter depends on whether native PHLDB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHLDB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHLDB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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