Seroatlas · Human Serome Atlas

MYD88

Myeloid differentiation primary response protein MyD88

Also known as: MYD88_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99836
Gene
MYD88
Ensembl
ENSG00000172936
Chromosome
3
Canonical length
296 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Mitochondria,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q99836|MYD88
     1  MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL AEEMDFEYLE
    61  IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD VLLELGPSIE EDCQKYILKQ
   121  QQEEAEKPLQ VAAVDSSVPR TAELAGITTL DDPLGHMPER FDAFICYCPS DIQFVQEMIR
   181  QLEQTNYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA
   241  LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYD88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 44 nTPM
  • liver: 43 nTPM
  • esophagus: 41 nTPM
  • appendix: 34 nTPM
  • bone marrow: 33 nTPM
  • small intestine: 29 nTPM

Single-cell type

  • neutrophils: 255 nCPM
  • esophageal apical cells: 111 nCPM
  • monocytes: 111 nCPM
  • kupffer cells: 95 nCPM
  • ocular epithelial cells: 65 nCPM
  • neutrophil progenitors: 62 nCPM

Immune cell

  • non-classical monocyte: 440 nTPM
  • intermediate monocyte: 334 nTPM
  • eosinophil: 298 nTPM
  • basophil: 289 nTPM
  • neutrophil: 288 nTPM
  • total PBMC: 259 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • thalamus: 10 nTPM
  • spinal cord: 9.3 nTPM
  • white matter: 8.7 nTPM
  • pons: 7.5 nTPM
  • choroid plexus: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYD88.

Disease | AllUniProt

Conditions MYD88 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 192 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pyogenic bacterial infections due to MyD88 deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.12
gnomAD missense Z
1.11
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYD88 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYD88 as an antibody target. Whether an autoantibody or antibody against MYD88 could matter depends on whether native MYD88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYD88 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYD88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYD88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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