Seroatlas · Human Serome Atlas

MEX3C

RNA-binding E3 ubiquitin-protein ligase MEX3C

Also known as: FLJ38871, MEX3C_HUMAN, RKHD2, RNF194

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5U5Q3
Gene: MEX3C
Ensembl: ENSG00000176624
Chromosome: 18
Canonical length: 659 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>Q5U5Q3|MEX3C
     1  MPSGSSAALA LAAAPAPLPQ PPPPPPPPPP PLPPPSGGPE LEGDGLLLRE RLAALGLDDP
    61  SPAEPGAPAL RAPAAAAQGQ ARRAAELSPE ERAPPGRPGA PEAAELELEE DEEEGEEAEL
   121  DGDLLEEEEL EEAEEEDRSS LLLLSPPAAT ASQTQQIPGG SLGSVLLPAA RFDAREAAAA
   181  AAAAGVLYGG DDAQGMMAAM LSHAYGPGGC GAAAAALNGE QAALLRRKSV NTTECVPVPS
   241  SEHVAEIVGR QGCKIKALRA KTNTYIKTPV RGEEPIFVVT GRKEDVAMAK REILSAAEHF
   301  SMIRASRNKN GPALGGLSCS PNLPGQTTVQ VRVPYRVVGL VVGPKGATIK RIQQQTHTYI
   361  VTPSRDKEPV FEVTGMPENV DRAREEIEMH IAMRTGNYIE LNEENDFHYN GTDVSFEGGT
   421  LGSAWLSSNP VPPSRARMIS NYRNDSSSSL GSGSTDSYFG SNRLADFSPT SPFSTGNFWF
   481  GDTLPSVGSE DLAVDSPAFD SLPTSAQTIW TPFEPVNPLS GFGSDPSGNM KTQRRGSQPS
   541  TPRLSPTFPE SIEHPLARRV RSDPPSTGNH VGLPIYIPAF SNGTNSYSSS NGGSTSSSPP
   601  ESRRKHDCVI CFENEVIAAL VPCGHNLFCM ECANKICEKR TPSCPVCQTA VTQAIQIHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEX3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

testis: 111 nTPM
bone marrow: 47 nTPM
thymus: 38 nTPM
tonsil: 25 nTPM
lymph node: 22 nTPM
ovary: 21 nTPM

Single-cell type

late spermatids: 849 nCPM
early spermatids: 773 nCPM
late primary spermatocytes: 164 nCPM
nk-cells: 76 nCPM
megakaryocytes: 50 nCPM
epididymal clear cells: 45 nCPM

Immune cell

basophil: 9.8 nTPM
NK-cell: 3.4 nTPM
memory CD4 T-cell: 2.4 nTPM
memory CD8 T-cell: 2.4 nTPM
gdT-cell: 2.3 nTPM
naive CD8 T-cell: 2.3 nTPM

Brain region

cerebellum: 28 nTPM
white matter: 26 nTPM
spinal cord: 25 nTPM
medulla oblongata: 24 nTPM
hippocampal formation: 24 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.86
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEX3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEX3C as an antibody target. Whether an autoantibody or antibody against MEX3C could matter depends on whether native MEX3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEX3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEX3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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