Seroatlas · Human Serome Atlas

PPM1G

Protein phosphatase 1G

Also known as: PP2CG, PP2Cgamma, PPM1G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15355
Gene
PPM1G
Ensembl
ENSG00000115241
Chromosome
2
Canonical length
546 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>O15355|PPM1G
     1  MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD
    61  GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR
   121  PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE
   181  PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS
   241  CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
   301  AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL
   361  DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA
   421  LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL
   481  DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK
   541  KKAKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
232 nTPM

Expression across tissuesHPA

Tissue

  • testis: 232 nTPM
  • skeletal muscle: 96 nTPM
  • tonsil: 71 nTPM
  • bone marrow: 69 nTPM
  • esophagus: 63 nTPM
  • thymus: 60 nTPM

Single-cell type

  • late spermatids: 5,464 nCPM
  • late primary spermatocytes: 1,906 nCPM
  • early spermatids: 1,469 nCPM
  • early primary spermatocytes: 457 nCPM
  • differentiating spermatogonia: 326 nCPM
  • esophageal apical cells: 288 nCPM

Immune cell

  • plasmacytoid DC: 92 nTPM
  • T-reg: 89 nTPM
  • non-classical monocyte: 72 nTPM
  • basophil: 68 nTPM
  • myeloid DC: 65 nTPM
  • memory CD4 T-cell: 61 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • hypothalamus: 33 nTPM
  • thalamus: 32 nTPM
  • midbrain: 32 nTPM
  • medulla oblongata: 31 nTPM
  • pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
3.34
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPM1G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1G as an antibody target. Whether an autoantibody or antibody against PPM1G could matter depends on whether native PPM1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPM1G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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