Seroatlas · Human Serome Atlas

RNF10

E3 ubiquitin-protein ligase RNF10

Also known as: KIAA0262, RIE2, RNF10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5U6
Gene: RNF10
Ensembl: ENSG00000022840
Chromosome: 12
Canonical length: 811 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

811 residues, UniProt reviewed canonical sequence.

>Q8N5U6|RNF10
     1  MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS
    61  KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA
   121  EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL
   181  FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC
   241  GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
   301  KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK
   361  HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV
   421  LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG
   481  TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK
   541  ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
   601  KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS
   661  TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK
   721  AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA
   781  TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 292 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 292 nTPM
tongue: 195 nTPM
heart muscle: 175 nTPM
bone marrow: 171 nTPM
kidney: 109 nTPM
choroid plexus: 101 nTPM

Single-cell type

neutrophils: 596 nCPM
esophageal apical cells: 460 nCPM
erythrocytes: 296 nCPM
neutrophil progenitors: 225 nCPM
platelets: 213 nCPM
late primary spermatocytes: 194 nCPM

Immune cell

eosinophil: 174 nTPM
basophil: 154 nTPM
neutrophil: 119 nTPM
T-reg: 60 nTPM
myeloid DC: 60 nTPM
non-classical monocyte: 55 nTPM

Brain region

choroid plexus: 100 nTPM
white matter: 92 nTPM
midbrain: 89 nTPM
hippocampal formation: 84 nTPM
thalamus: 83 nTPM
basal ganglia: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.16
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF10 as an antibody target. Whether an autoantibody or antibody against RNF10 could matter depends on whether native RNF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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