ANAPC11
Anaphase-promoting complex subunit 11
Also known as: APC11, APC11_HUMAN, Apc11p, HSPC214, MGC882
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYG5
- Gene
- ANAPC11
- Ensembl
- ENSG00000141552
- Chromosome
- 17
- Canonical length
- 84 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
84 residues, UniProt reviewed canonical sequence.
>Q9NYG5|ANAPC11
1 MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI
61 LKWLHAQQVQ QHCPMCRQEW KFKELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANAPC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 285 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 285 nTPM
- heart muscle: 227 nTPM
- amygdala: 214 nTPM
- testis: 185 nTPM
- cerebral cortex: 184 nTPM
- liver: 181 nTPM
Single-cell type
- late spermatids: 1,837 nCPM
- late primary spermatocytes: 854 nCPM
- esophageal apical cells: 766 nCPM
- extravillous trophoblasts: 656 nCPM
- esophageal suprabasal cells: 590 nCPM
- syncytiotrophoblasts: 589 nCPM
Immune cell
- plasmacytoid DC: 583 nTPM
- total PBMC: 507 nTPM
- basophil: 497 nTPM
- classical monocyte: 421 nTPM
- eosinophil: 420 nTPM
- intermediate monocyte: 361 nTPM
Brain region
- white matter: 88 nTPM
- thalamus: 81 nTPM
- cerebellum: 75 nTPM
- spinal cord: 74 nTPM
- medulla oblongata: 72 nTPM
- basal ganglia: 68 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0.33
- gnomAD missense Z
- 1.12
- DepMap mean gene effect
- -1.43
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anaphase-promoting complex-dependent catabolic process
- cell division
- mitotic cell cycle
- positive regulation of mitotic metaphase/anaphase transition
- protein branched polyubiquitination
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein ubiquitination
- regulation of meiotic cell cycle
- regulation of mitotic cell cycle
- ubiquitin-dependent protein catabolic process
Molecular functions
- cullin family protein binding
- G protein-coupled receptor binding
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- ubiquitin-ubiquitin ligase activity
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, RING-type
- Zinc finger, RING/FYVE/PHD-type
- RING-box E3 Ubiquitin Ligase
- Anaphase-promoting complex subunit 11, RING-H2 finger
- Anaphase-promoting complex subunit 11 RING-H2 finger
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ANAPC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANAPC11 as an antibody target. Whether an autoantibody or antibody against ANAPC11 could matter depends on whether native ANAPC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANAPC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANAPC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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