Seroatlas · Human Serome Atlas

RNF115

E3 ubiquitin-protein ligase RNF115

Also known as: CL469780, RN115_HUMAN, ZNF364

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4L5
Gene: RNF115
Ensembl: ENSG00000265491
Chromosome: 1
Canonical length: 304 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in negative regulation of signal transduction; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q9Y4L5|RNF115
     1  MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG
    61  SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR
   121  LPLGRRYRSR GSSRPDRSPA IEGILQHIFA GFFANSAIPG SPHPFSWSGM LHSNPGDYAW
   181  GQTGLDAIVT QLLGQLENTG PPPADKEKIT SLPTVTVTQE QVDMGLECPV CKEDYTVEEE
   241  VRQLPCNHFF HSSCIVPWLE LHDTCPVCRK SLNGEDSTRQ SQSTEASASN RFSNDSQLHD
   301  RWTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF115 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 31 nTPM
tongue: 24 nTPM
heart muscle: 23 nTPM
cerebellum: 22 nTPM
blood vessel: 16 nTPM
retina: 13 nTPM

Single-cell type

myonuclei: 579 nCPM
podocytes: 314 nCPM
thymic myoid cells: 313 nCPM
nk-cells: 238 nCPM
smooth muscle cells: 210 nCPM
distal convoluted tubule cells: 203 nCPM

Immune cell

basophil: 6.3 nTPM
eosinophil: 1.6 nTPM
NK-cell: 1.6 nTPM
memory B-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM
memory CD8 T-cell: 1.4 nTPM

Brain region

cerebellum: 34 nTPM
cerebral cortex: 19 nTPM
amygdala: 17 nTPM
thalamus: 17 nTPM
basal ganglia: 16 nTPM
midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF115.

Disease | ImmuneIEDB

Conditions an epitope on RNF115 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF115 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF115 as an antibody target. Whether an autoantibody or antibody against RNF115 could matter depends on whether native RNF115 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF115 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF115 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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