Seroatlas · Human Serome Atlas

PJA2

E3 ubiquitin-protein ligase Praja-2

Also known as: KIAA0438, Neurodap1, PJA2_HUMAN, PRAJA2, RNF131

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43164
Gene
PJA2
Ensembl
ENSG00000198961
Chromosome
5
Canonical length
708 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Primary cilium,Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of macrophage activation; and regulation of signal transduction. Located in centriolar satellite; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

708 residues, UniProt reviewed canonical sequence.

>O43164|PJA2
     1  MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG
    61  DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET EIPTCGSALN QTTESSQSFV
   121  AVHHSEEGRD TLGSSTNLHN HSEGEYIPGA CSASSVQNGI ALVHTDSYDP DGKHGEDNDH
   181  LQLSAEVVEG SRYQESLGNT VFELENREAE AYTGLSPPVP SFNCEVRDEF EELDSVPLVK
   241  SSAGDTEFVH QNSQEIQRSS QDEMVSTKQQ NNTSQERQTE HSPEDAACGP GHICSEQNTN
   301  DREKNHGSSP EQVVRPKVRK LISSSQVDQE TGFNRHEAKQ RSVQRWREAL EVEESGSDDL
   361  LIKCEEYDGE HDCMFLDPPY SRVITQRETE NNQMTSESGA TAGRQEVDNT FWNGCGDYYQ
   421  LYDKDEDSSE CSDGEWSASL PHRFSGTEKD QSSSDESWET LPGKDENEPE LQSDSSGPEE
   481  ENQELSLQEG EQTSLEEGEI PWLQYNEVNE SSSDEGNEPA NEFAQPAFML DGNNNLEDDS
   541  SVSEDLDVDW SLFDGFADGL GVAEAISYVD PQFLTYMALE ERLAQAMETA LAHLESLAVD
   601  VEVANPPASK ESIDGLPETL VLEDHTAIGQ EQCCPICCSE YIKDDIATEL PCHHFFHKPC
   661  VSIWLQKSGT CPVCRRHFPP AVIEASAAPS SEPDPDAPPS NDSIAEAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PJA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 144 nTPM
  • blood vessel: 96 nTPM
  • seminal vesicle: 87 nTPM
  • thyroid gland: 86 nTPM
  • bone marrow: 83 nTPM
  • parathyroid gland: 83 nTPM

Single-cell type

  • neutrophils: 726 nCPM
  • neutrophil progenitors: 361 nCPM
  • corticotrophs: 344 nCPM
  • lactotrophs: 267 nCPM
  • somatotrophs: 235 nCPM
  • smooth muscle cells: 234 nCPM

Immune cell

  • neutrophil: 49 nTPM
  • basophil: 33 nTPM
  • eosinophil: 29 nTPM
  • non-classical monocyte: 28 nTPM
  • T-reg: 21 nTPM
  • intermediate monocyte: 20 nTPM

Brain region

  • hypothalamus: 206 nTPM
  • cerebral cortex: 203 nTPM
  • basal ganglia: 191 nTPM
  • hippocampal formation: 189 nTPM
  • white matter: 181 nTPM
  • spinal cord: 166 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PJA2.

Disease | ImmuneIEDB

Conditions an epitope on PJA2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.02
gnomAD missense Z
0.43
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PJA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PJA2 as an antibody target. Whether an autoantibody or antibody against PJA2 could matter depends on whether native PJA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PJA2 is annotated at the cell surface, where native PJA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PJA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PJA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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