Seroatlas · Human Serome Atlas

PPP1R11

E3 ubiquitin-protein ligase PPP1R11

Also known as: CFAP255, HCG-V, HCGV, PP1RB_HUMAN, TCTE5, Tctex5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60927
Gene: PPP1R11
Ensembl: ENSG00000204619
Chromosome: 6
Canonical length: 126 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>O60927|PPP1R11
     1  MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC
    61  CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP
   121  PGPMQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

kidney: 68 nTPM
cerebral cortex: 63 nTPM
blood vessel: 59 nTPM
stomach: 58 nTPM
colon: 55 nTPM
amygdala: 55 nTPM

Single-cell type

late spermatids: 888 nCPM
early spermatids: 100 nCPM
breast lactating cells: 18 nCPM
other brain neurons: 17 nCPM
late primary spermatocytes: 17 nCPM
papillary tip epithelial cells: 16 nCPM

Immune cell

eosinophil: 13 nTPM
basophil: 12 nTPM
intermediate monocyte: 9.3 nTPM
T-reg: 8.4 nTPM
non-classical monocyte: 8 nTPM
naive B-cell: 7.2 nTPM

Brain region

cerebral cortex: 3.5 nTPM
white matter: 1.8 nTPM
medulla oblongata: 1.3 nTPM
pons: 1 nTPM
hippocampal formation: 0.9 nTPM
amygdala: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.36
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.98
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Type 1 protein phosphatase inhibitor
Protein phosphatase inhibitor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R11 as an antibody target. Whether an autoantibody or antibody against PPP1R11 could matter depends on whether native PPP1R11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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