Seroatlas · Human Serome Atlas

RNF126

E3 ubiquitin-protein ligase RNF126

Also known as: FLJ20552, RN126_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV68
Gene: RNF126
Ensembl: ENSG00000070423
Chromosome: 19
Canonical length: 311 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q9BV68|RNF126
     1  MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSTENG SAPSTAPTDQ
    61  SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA QADDGRDPES RRERDHPSRH
   121  RYGARQPRAR LTTRRATGRH EGVPTLEGII QQLVNGIITP ATIPSLGPWG VLHSNPMDYA
   181  WGANGLDAII TQLLNQFENT GPPPADKEKI QALPTVPVTE EHVGSGLECP VCKDDYALGE
   241  RVRQLPCNHL FHDGCIVPWL EQHDSCPVCR KSLTGQNTAT NPPGLTGVSF SSSSSSSSSS
   301  SPSNENATSN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF126 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
testis: 51 nTPM
skin: 48 nTPM
esophagus: 44 nTPM
liver: 43 nTPM
spleen: 32 nTPM

Single-cell type

late primary spermatocytes: 285 nCPM
esophageal basal cells: 176 nCPM
extravillous trophoblasts: 174 nCPM
esophageal apical cells: 167 nCPM
esophageal suprabasal cells: 165 nCPM
basal keratinocytes: 144 nCPM

Immune cell

T-reg: 28 nTPM
NK-cell: 28 nTPM
naive B-cell: 26 nTPM
gdT-cell: 25 nTPM
memory CD8 T-cell: 25 nTPM
memory B-cell: 24 nTPM

Brain region

cerebral cortex: 43 nTPM
white matter: 36 nTPM
pons: 30 nTPM
hippocampal formation: 28 nTPM
thalamus: 27 nTPM
amygdala: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Ring finger domain
E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon
zinc-ribbon

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF126 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF126 as an antibody target. Whether an autoantibody or antibody against RNF126 could matter depends on whether native RNF126 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF126 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF126 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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