Seroatlas · Human Serome Atlas

BFAR

Bifunctional apoptosis regulator

Also known as: BAR, BFAR_HUMAN, RNF47

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZS9
Gene
BFAR
Ensembl
ENSG00000103429
Chromosome
16
Canonical length
450 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9NZS9|BFAR
     1  MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL
    61  WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ
   121  KYGNDQIPLA PNTGRANQQM GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA
   181  KWTAEEVVLW LEQLGPWASL YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL
   241  MELERVKALG VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LSLLYLYLFD YTDTFLPFIH
   301  TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR
   361  FLIINAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV STQGLFVAMF WPLIPQFVCN
   421  CLFYWALYFN PIINIDLVVK ELRRLETQVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BFAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 44 nTPM
  • skeletal muscle: 44 nTPM
  • adipose tissue: 35 nTPM
  • lung: 35 nTPM
  • blood vessel: 33 nTPM
  • breast: 32 nTPM

Single-cell type

  • proximal tubule cells: 50 nCPM
  • renal collecting duct intercalated cells: 31 nCPM
  • choroid plexus epithelial cells: 30 nCPM
  • microglia: 25 nCPM
  • podocytes: 24 nCPM
  • papillary tip epithelial cells: 24 nCPM

Immune cell

  • T-reg: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • memory CD8 T-cell: 12 nTPM
  • gdT-cell: 12 nTPM
  • memory B-cell: 11 nTPM
  • naive CD8 T-cell: 10 nTPM

Brain region

  • cerebellum: 20 nTPM
  • choroid plexus: 20 nTPM
  • white matter: 20 nTPM
  • medulla oblongata: 19 nTPM
  • basal ganglia: 19 nTPM
  • thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BFAR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BFAR as an antibody target. Whether an autoantibody or antibody against BFAR could matter depends on whether native BFAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BFAR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BFAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BFAR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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