Seroatlas · Human Serome Atlas

RCHY1

RING finger and CHY zinc finger domain-containing protein 1

Also known as: ARNIP, CHIMP, DKFZp586C1620, PIRH2, PRO1996, RNF199, ZCHY, ZN363_HUMAN, ZNF363

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PM5
Gene
RCHY1
Ensembl
ENSG00000163743
Chromosome
4
Canonical length
261 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q96PM5|RCHY1
     1  MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH QLDRFKVKEV
    61  QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY HCENCGICRI GPKEDFFHCL
   121  KCNLCLAMNL QGRHKCIENV SRQNCPICLE DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG
   181  YRCPLCMHSA LDMTRYWRQL DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC
   241  KICESYNTAQ AGGRRISLDQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCHY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 22 nTPM
  • thyroid gland: 18 nTPM
  • bone marrow: 17 nTPM
  • breast: 16 nTPM
  • heart muscle: 16 nTPM
  • skeletal muscle: 16 nTPM

Single-cell type

  • breast lactating cells: 131 nCPM
  • parietal cells: 127 nCPM
  • late spermatids: 106 nCPM
  • neutrophil progenitors: 92 nCPM
  • kupffer cells: 78 nCPM
  • late primary spermatocytes: 74 nCPM

Immune cell

  • basophil: 28 nTPM
  • eosinophil: 9.7 nTPM
  • classical monocyte: 9.3 nTPM
  • myeloid DC: 8.1 nTPM
  • MAIT T-cell: 7.7 nTPM
  • intermediate monocyte: 5.8 nTPM

Brain region

  • cerebellum: 18 nTPM
  • thalamus: 14 nTPM
  • hypothalamus: 14 nTPM
  • midbrain: 13 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCHY1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 40 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.07
gnomAD missense Z
1.2
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCHY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCHY1 as an antibody target. Whether an autoantibody or antibody against RCHY1 could matter depends on whether native RCHY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCHY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCHY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCHY1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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