Seroatlas · Human Serome Atlas

BIRC3

Baculoviral IAP repeat-containing protein 3

Also known as: API2, BIRC3_HUMAN, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13489
Gene
BIRC3
Ensembl
ENSG00000023445
Chromosome
11
Canonical length
604 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>Q13489|BIRC3
     1  MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV
    61  NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS
   121  THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP
   181  LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ
   241  DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR
   301  CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS
   361  IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL
   421  LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD
   481  VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS
   541  DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR
   601  TFLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIRC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 132 nTPM
  • tonsil: 126 nTPM
  • appendix: 99 nTPM
  • small intestine: 84 nTPM
  • spleen: 69 nTPM
  • thymus: 55 nTPM

Single-cell type

  • enterocytes: 1,049 nCPM
  • mast cells: 869 nCPM
  • cdc: 836 nCPM
  • fallopian secretory cells: 530 nCPM
  • plasma cells: 500 nCPM
  • pancreatic duct cells: 446 nCPM

Immune cell

  • memory B-cell: 210 nTPM
  • naive B-cell: 161 nTPM
  • T-reg: 84 nTPM
  • memory CD4 T-cell: 42 nTPM
  • naive CD4 T-cell: 29 nTPM
  • memory CD8 T-cell: 14 nTPM

Brain region

  • hypothalamus: 5.1 nTPM
  • cerebral cortex: 4.9 nTPM
  • white matter: 4.9 nTPM
  • choroid plexus: 4.7 nTPM
  • hippocampal formation: 3.4 nTPM
  • midbrain: 3.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BIRC3.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.07
gnomAD missense Z
1.15
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIRC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIRC3 as an antibody target. Whether an autoantibody or antibody against BIRC3 could matter depends on whether native BIRC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIRC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIRC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BIRC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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