Seroatlas · Human Serome Atlas

OTUB1

Ubiquitin thioesterase OTUB1

Also known as: FLJ20113, FLJ40710, OTUB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FW1
Gene
OTUB1
Ensembl
ENSG00000167770
Chromosome
11
Canonical length
271 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q96FW1|OTUB1
     1  MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE
    61  YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK
   121  SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS
   181  GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE
   241  GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 126 nTPM
  • hippocampal formation: 102 nTPM
  • cerebellum: 92 nTPM
  • amygdala: 91 nTPM
  • basal ganglia: 88 nTPM
  • esophagus: 83 nTPM

Single-cell type

  • syncytiotrophoblasts: 233 nCPM
  • esophageal apical cells: 185 nCPM
  • cytotrophoblasts: 167 nCPM
  • migrating cytotrophoblasts: 165 nCPM
  • esophageal suprabasal cells: 160 nCPM
  • oocytes: 138 nCPM

Immune cell

  • total PBMC: 310 nTPM
  • intermediate monocyte: 241 nTPM
  • basophil: 227 nTPM
  • T-reg: 224 nTPM
  • non-classical monocyte: 217 nTPM
  • myeloid DC: 201 nTPM

Brain region

  • cerebral cortex: 134 nTPM
  • basal ganglia: 130 nTPM
  • hippocampal formation: 126 nTPM
  • pons: 107 nTPM
  • white matter: 107 nTPM
  • thalamus: 106 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
2.19
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTUB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUB1 as an antibody target. Whether an autoantibody or antibody against OTUB1 could matter depends on whether native OTUB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OTUB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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