Seroatlas · Human Serome Atlas

RNF26

E3 ubiquitin-protein ligase RNF26

Also known as: MGC2642, RNF26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY78
Gene
RNF26
Ensembl
ENSG00000173456
Chromosome
11
Canonical length
433 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q9BY78|RNF26
     1  MEAVYLVVNG LGLVLDVLTL VLDLNFLLVS SLLASLAWLL AFVYNLPHTV LTSLLHLGRG
    61  VLLSLLALIE AVVRFTCGGL QALCTLLYSC CSGLESLKLL GHLASHGALR SREILHRGVL
   121  NVVSSGHALL RQACDICAIA MSLVAYVINS LVNICLIGTQ NLFSLVLALW DAVTGPLWRM
   181  TDVVAAFLAH ISSSAVAMAI LLWTPCQLAL ELLASAARLL ASFVLVNLTG LVLLACVLAV
   241  TVTVLHPDFT LRLATQALSQ LHARPSYHRL REDVMRLSRL ALGSEAWRRV WSRSLQLASW
   301  PNRGGAPGAP QGDPMRVFSV RTRRQDTLPE AGRRSEAEEE EARTIRVTPV RGRERLNEEE
   361  PPGGQDPWKL LKEQEERKKC VICQDQSKTV LLLPCRHLCL CQACTEILMR HPVYHRNCPL
   421  CRRGILQTLN VYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • liver: 22 nTPM
  • endometrium: 21 nTPM
  • bone marrow: 21 nTPM
  • esophagus: 20 nTPM
  • urinary bladder: 19 nTPM
  • blood vessel: 18 nTPM

Single-cell type

  • extravillous trophoblasts: 79 nCPM
  • migrating cytotrophoblasts: 60 nCPM
  • cytotrophoblasts: 49 nCPM
  • esophageal basal cells: 32 nCPM
  • enteric transient amplifying cells: 32 nCPM
  • decidual stromal cells: 31 nCPM

Immune cell

  • total PBMC: 25 nTPM
  • classical monocyte: 22 nTPM
  • gdT-cell: 21 nTPM
  • non-classical monocyte: 20 nTPM
  • intermediate monocyte: 19 nTPM
  • myeloid DC: 19 nTPM

Brain region

  • pons: 26 nTPM
  • cerebral cortex: 25 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 24 nTPM
  • cerebellum: 22 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.65
gnomAD missense Z
1.18
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF26 as an antibody target. Whether an autoantibody or antibody against RNF26 could matter depends on whether native RNF26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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