Seroatlas · Human Serome Atlas

RNF43

E3 ubiquitin-protein ligase RNF43

Also known as: DKFZp781H0392, FLJ20315, RNF43_HUMAN, URCC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q68DV7
Gene
RNF43
Ensembl
ENSG00000108375
Chromosome
17
Canonical length
783 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q68DV7|RNF43
     1  MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK
    61  LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL
   121  SLASKARMAG ERGASAVLFD ITEDRAAAEQ LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ
   181  KAHVRIELKE PPAWPDYDVW ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI
   241  SQLATRRYQA SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD
   301  PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH YHLPAAYLLG
   361  PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG EQQRLAGAQH PYAQGWGLSH
   421  LQSTSQHPAA CPVPLRRARP PDSSGSGESY CTERSGYLAD GPASDSSSGP CHGSSSDSVV
   481  NCTDISLQGV HGSSSTFCSS LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG
   541  ETQVSSHVHY HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR
   601  SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR HPQRKRRGGP
   661  SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI CGPPGLDKRL LPETPGPCYS
   721  NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD TAEGRPCPYP HCQVLSAQPG SEEELEELCE
   781  QAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 21 nTPM
  • rectum: 18 nTPM
  • small intestine: 16 nTPM
  • colon: 13 nTPM
  • adrenal gland: 11 nTPM
  • skin: 11 nTPM

Single-cell type

  • ependymal cells: 166 nCPM
  • bergmann glia: 90 nCPM
  • distal convoluted tubule cells: 86 nCPM
  • loop of henle epithelial cells: 70 nCPM
  • renal connecting tubule cells: 62 nCPM
  • papillary tip epithelial cells: 55 nCPM

Immune cell

  • MAIT T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • cerebellum: 20 nTPM
  • midbrain: 6.2 nTPM
  • basal ganglia: 5.6 nTPM
  • cerebral cortex: 4.7 nTPM
  • thalamus: 4 nTPM
  • medulla oblongata: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF43.

Disease | AllUniProt

Conditions RNF43 is implicated in, by any mechanism.

  • Sessile serrated polyposis cancer syndrome (SSPCS) MIM:617108

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 1,366 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Sessile serrated polyposis cancer syndrome
  • Neoplasm
  • Colon serrated polyposis

Disease | ImmuneIEDB

Conditions an epitope on RNF43 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.73
gnomAD missense Z
1.85
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF43 as an antibody target. Whether an autoantibody or antibody against RNF43 could matter depends on whether native RNF43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF43 is annotated at the cell surface, where native RNF43 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RNF43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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