RNF11
RING finger protein 11
Also known as: CGI-123, MGC51169, RNF11_HUMAN, Sid1669p
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y3C5
- Gene
- RNF11
- Ensembl
- ENSG00000123091
- Chromosome
- 1
- Canonical length
- 154 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>Q9Y3C5|RNF11
1 MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPVYH PTPSQTRLAT
61 QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI
121 YHLDCIDDWL MRSFTCPSCM EPVDAALLSS YETNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 128 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 128 nTPM
- amygdala: 109 nTPM
- skeletal muscle: 100 nTPM
- hippocampal formation: 94 nTPM
- hypothalamus: 89 nTPM
- tongue: 89 nTPM
Single-cell type
- platelets: 743 nCPM
- esophageal apical cells: 699 nCPM
- neutrophils: 348 nCPM
- syncytiotrophoblasts: 318 nCPM
- late spermatids: 293 nCPM
- esophageal suprabasal cells: 199 nCPM
Immune cell
- basophil: 22 nTPM
- eosinophil: 7.1 nTPM
- plasmacytoid DC: 6.7 nTPM
- neutrophil: 6.2 nTPM
- MAIT T-cell: 3.9 nTPM
- memory CD8 T-cell: 3.6 nTPM
Brain region
- cerebral cortex: 126 nTPM
- midbrain: 120 nTPM
- thalamus: 120 nTPM
- hypothalamus: 117 nTPM
- basal ganglia: 114 nTPM
- pons: 112 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.69
- gnomAD pLI
- 0.58
- gnomAD missense Z
- 1.48
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, RING-type
- Zinc finger, RING/FYVE/PHD-type
- Ring finger domain
- RING finger protein 11, RING-H2 finger
- Ubiquitin-editing complex component
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RNF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNF11 as an antibody target. Whether an autoantibody or antibody against RNF11 could matter depends on whether native RNF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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