Seroatlas · Human Serome Atlas

TRIM8

E3 ubiquitin-protein ligase TRIM8

Also known as: GERP, RNF27, TRIM8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZR9
Gene
TRIM8
Ensembl
ENSG00000171206
Chromosome
10
Canonical length
551 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9BZR9|TRIM8
     1  MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN
    61  QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ
   121  THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC
   181  DVEIRRNEIR KMLMKQQDRL EEREQDIEDQ LYKLESDKRL VEEKVNQLKE EVRLQYEKLH
   241  QLLDEDLRQT VEVLDKAQAK FCSENAAQAL HLGERMQEAK KLLGSLQLLF DKTEDVSFMK
   301  NTKSVKILMD RTQTCTSSSL SPTKIGHLNS KLFLNEVAKK EKQLRKMLEG PFSTPVPFLQ
   361  SVPLYPCGVS SSGAEKRKHS TAFPEASFLE TSSGPVGGQY GAAGTASGEG QSGQPLGPCS
   421  STQHLVALPG GAQPVHSSPV FPPSQYPNGS AAQQPMLPQY GGRKILVCSV DNCYCSSVAN
   481  HGGHQPYPRS GHFPWTVPSQ EYSHPLPPTP SVPQSLPSLA VRDWLDASQQ PGHQDFYRVY
   541  GQPSTKHYVT S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 73 nTPM
  • kidney: 72 nTPM
  • skeletal muscle: 72 nTPM
  • adipose tissue: 70 nTPM
  • blood vessel: 69 nTPM
  • basal ganglia: 66 nTPM

Single-cell type

  • salivary ionocytes: 98 nCPM
  • salivary duct cells: 79 nCPM
  • neutrophils: 78 nCPM
  • epididymal clear cells: 78 nCPM
  • fallopian tube ciliated cells: 73 nCPM
  • conjunctival goblet cells: 70 nCPM

Immune cell

  • neutrophil: 18 nTPM
  • basophil: 14 nTPM
  • plasmacytoid DC: 13 nTPM
  • memory B-cell: 9 nTPM
  • T-reg: 7.5 nTPM
  • naive B-cell: 7.4 nTPM

Brain region

  • thalamus: 177 nTPM
  • midbrain: 152 nTPM
  • medulla oblongata: 145 nTPM
  • basal ganglia: 137 nTPM
  • amygdala: 137 nTPM
  • pons: 133 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM8.

Disease | AllUniProt

Conditions TRIM8 is implicated in, by any mechanism.

  • Focal segmental glomerulosclerosis and neurodevelopmental syndrome (FSGSNEDS) MIM:619428

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 463 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
2.74
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM8 as an antibody target. Whether an autoantibody or antibody against TRIM8 could matter depends on whether native TRIM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...