MYLIP

Protein identityUniProt · HPA

UniProt accession

Q8WY64

Gene

MYLIP

Ensembl

ENSG00000007944

Chromosome

6

Canonical length

445 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q8WY64|MYLIP
     1  MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN
    61  RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS
   121  ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS
   181  AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT
   241  VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF
   301  LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC
   361  SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV
   421  CRSRVEHVQH VYLPTHTSLL NLTVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYLIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

87 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.18

gnomAD missense Z

1.08

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol homeostasis
• negative regulation of low-density lipoprotein particle clearance
• negative regulation of neuron projection development
• nervous system development
• positive regulation of protein catabolic process
• protein destabilization
• protein ubiquitination
• ubiquitin-dependent protein catabolic process
• regulation of low-density lipoprotein particle receptor catabolic process

Molecular functions

• cytoskeletal protein binding
• ubiquitin protein ligase activity
• ubiquitin-protein transferase activity
• zinc ion binding

Cellular components

• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• FERM domain
• Ezrin/radixin/moesin-like
• Zinc finger, RING-type
• PH-like domain superfamily
• Zinc finger, RING/FYVE/PHD-type
• FERM/acyl-CoA-binding protein superfamily
• FERM, N-terminal
• FERM, C-terminal PH-like domain
• FERM central domain
• Band 4.1 domain
• Ubiquitin-like domain superfamily
• FERM superfamily, second domain
• FERM central domain
• FERM N-terminal domain
• FERM C-terminal PH-like domain
• Zinc finger, C3HC4 type (RING finger)
• MYLIP, FERM domain C-lobe

KeywordsUniProt

• Cell membrane
• Cytoplasm
• Iron
• Membrane
• Metal-binding
• Transferase
• Ubl conjugation
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of MYLIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBE2D1
• CNPY2
• LNX2